Clinical Research Directory

Inclusion Criteria: * Diffuse midline glioma diagnosis: verified radiologically or histologically Biopsy is not mandatory for REMIT * Age ≥ 12 months to ≤21 years. * Min. 180 days/6 months have elapsed from the first day of the 1st RT course * 1st course of radiotherapy * Full recovery from all acute and subacute toxicities of 1st RT course * Clinical progression of symptoms and/or radiographic progression * Karnofsky performance status scale or Lansky Play Scale \> 50% The performance status should not take the neurological deficits per se into account. NB: Children and adults with a worsening performance status due to glioma-related motor deficit can be included. * Life expectancy \> 12 weeks after start of reRT * Signed informed consent by patient and/or parents or legal guardian Exclusion Criteria: * Presence of leptomeningeal spread or multifocal disease on MRI at progression * Other co-morbidity that according to the treating physician would impair participation in the study * \>1 course of radiotherapy * Neurofibromatosis type 1 * Inability to complete the medical follow-up (geographic, social, or mental reasons)