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Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Sponsor: University of Delaware
Summary
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.
Key Details
Gender
All
Age Range
40 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-03-05
Completion Date
2028-07-01
Last Updated
2026-03-24
Healthy Volunteers
Yes
Conditions
Interventions
Furosemide (Diuretic)
The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.
Hypertonic Saline Infusion
3% Hypertonic saline infusion to acutely increase sodium and osmolality
Locations (1)
University of Delaware
Newark, Delaware, United States