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Prognostic Markers for a Better Follow-up in Head and Neck Cancer.
Sponsor: Karolinska Institutet
Summary
To identify tumor specific DNA mutations and aberrations and to follow these in blood over time to predict treatment response/survival and secondly to correlate presence of these markers in blood to pathological parameters (LVI, Pn, WPOI and margins), radiological findings and to tumor stage.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2014-02-12
Completion Date
2026-05-31
Last Updated
2024-03-05
Healthy Volunteers
No
Conditions
Interventions
DNA exome sequencing of tumor and blood
A piece from tumor and a blood sample will be collected during surgery. DNA will be extracted and presence of tumor specific mutations/aberrations will be analysed with a DNA exome seq panel. Presence of identified markers will be followed in blood samples with the same panel and these blood samples will be collected in routine follow-up during the first two years. Presence of markers over time in blood will be correlated to outcomes 1-5.
Locations (1)
Karolinska universitetssjukhuset
Stockholm, Sweden