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MultiSCRIPT-Cycle 1: Personalized Medicine in Multiple Sclerosis - Pragmatic Platform Trial Embedded Within the SMSC
Sponsor: University Hospital, Basel, Switzerland
Summary
This is a randomized pragmatic clinical trial fully embedded in the Swiss Multiple Sclerosis Cohort to assess whether sNfL biomarker monitoring improves patient-relevant outcomes and care of patients with relapsing-remitting (RR)MS by either increasing the proportion of patients with no evidence of disease activity (EDA) or by improving patients' health-related quality of life.
Official title: A Multicenter, Randomized Pragmatic Platform Trial Embedded Within the Swiss Multiple Sclerosis Cohort (SMSC) on Neurofilament Light Chain Monitoring Added to Usual Care to Inform Personalized Treatment Decisions in Multiple Sclerosis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
920
Start Date
2023-02-05
Completion Date
2027-05
Last Updated
2025-05-11
Healthy Volunteers
No
Conditions
Interventions
serum Neurofilament Filament Light chain (sNfL) monitoring
the intervention consist of a blood draw and providing the sNfL information to the treating physician
Locations (8)
University Hospital Basel
Basel, Canton of Basel-City, Switzerland
Kantonsspital Aarau
Aarau, Switzerland
Inselspital Bern
Bern, Switzerland
Hôpitaux Universitaires de Genève
Geneva, Switzerland
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Ospedale Regionale di Lugano, sede Civico
Lugano, Switzerland
Kantonsspital St.Gallen
Sankt Gallen, Switzerland
UniversitätsSpital Zürich
Zurich, Switzerland