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Nutritional Status in Subacute Stroke Patients Under Rehabilitation 2.0
Sponsor: Fondazione Don Carlo Gnocchi Onlus
Summary
The Nutristroke study's findings revealed a malnutrition scenario in post-stroke patients undergoing rehabilitation. This has highlighted the significance of a correct nutritional status assessment upon admission to a rehabilitation unit. The aim of Nutristroke2, therefore, is the assessment of nutritional status, dietary intake, dysphagia, the presence of stroke-related sarcopenia, and systemic oxidative status in patients with subacute stroke outcomes before and after rehabilitation treatment. A secondary aim is to assess whether there is any correlation between nutritional status, dietary intake, dysphagia, sarcopenia, and systemic oxidative status with rehabilitation outcomes.
Official title: Study of Nutritional Status in Subacute Stroke Patients Under Rehabilitation Treatment
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
55
Start Date
2024-05-29
Completion Date
2025-12
Last Updated
2024-06-18
Healthy Volunteers
No
Conditions
Interventions
robotic assisted intervention
Robotic treatment of the upper limb (30 sessions, 5 times a week) using a set of 4 robotic devices: Motore (Humanware); Amadeo, Diego, Pablo (Tyromotion). The training will include motor-cognitive exercises specifically selected to train spatial attention, vision and working memory, praxis, executive function, and speed of processing.
hematochemical analysis
Blood samples of patients will be collected from patients in the early morning (7:30-9:00 a.m.) after an overnight fast at T0 and at T1. Sera samples will be separated by centrifugation (3,000 rpm, 10 min, and 4 °C), divided into 0.5 mL aliquots, and rapidly stored at -80 °C. Subjects' and reference samples were thawed just before the diagnostic test.
BIA, hand grip
bioimpedentiometric analyses of muscular mass (T0 and T1), muscular force with hand grip
nutritional assessment, MNA,
nutritional status assessment will be performed by: body mass index measurements, (height and weight measurements at T0 and at T1); a Mini Nutritional Assessment survey will be administered to patients at admission; a food questionnaire will be administered to patients during from T0 to T1.
stool sampling
stool will be collected at T0 and at T1
urine sampling
the first morning urine will be collected at T0 and at T1
indirect calorimetry analysis
indirect calorimetry analysis with K5 (COSMED, Italy) during six minute walk test or timed up and go test.
Locations (1)
Fondazione Don Carlo Gnocchi, Santa Maria della Provvidenza Center
Roma, RM, Italy