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Looking for a Blood Epigenetic Signature to Predict Female Infertility
Sponsor: Università Vita-Salute San Raffaele
Summary
The present research project aims to study the DNAm mechanisms underlying the reduction of fertility due to the progressive depletion of oocyte quality. Specifically, our project aims to build an epigenetic clock for MGCs by using outcomes that are certainly related to female fertility. The validation of such findings will be carried out on peripheral blood in order to guarantee its non-invasiveness and allow for any clinical transferability. In order to identify a blood epigenetic signature able to predict female infertility, we planned to explore the problem from different points of view by conducting several studies in different settings.
Key Details
Gender
FEMALE
Age Range
18 Years - 43 Years
Study Type
OBSERVATIONAL
Enrollment
1456
Start Date
2023-10-16
Completion Date
2026-10-16
Last Updated
2023-10-24
Healthy Volunteers
Yes
Conditions
Interventions
search for epigenetic profile of infertility
examine the epigenetic profile of DNA extracted from MGCs and blood sample
Locations (1)
Università Vita Salute San Raffaele
Milan, Italy