Clinical Research Directory

Inclusion Criteria: 1. Patients who sign the informed consent form and are willing to complete the study according to the plan; 2. Aged from 18 to 80 years old; 3. ECOG equals 0 or 1; 4. Not receiving lung cancer surgery before; 5. Intraoperative or postoperative pathologic diagnosis of lung adenocarcinoma; 6. Single lung nodules with ground-glass dominant or pure ground-glass on CT, or multiple lung nodules with the major lesion being the aforementioned nodules; 7. The nodule has a consolidation-to-tumor ratio (CTR) between 0.25 and 0.5 (including 0.25 and 0.5), and the nodule size is less than or equal to 2 cm; 8. peripheral type of nodes, namely, nodes in the outer 1/3 of the lung field. 9. cT1N0M0 tumors; 10. Complete tumor resection by wedge resection as assessed by the surgeon; 11. Not receiving chemotherapy or radiotherapy before. Exclusion Criteria: 1. Postoperative pathologic diagnosis of adenocarcinoma in situ or minimally invasive adenocarcinoma. 2. CTR is not between 0.25-0.5 or nodule size greater than 2 cm; 3. Cannot be completely resected by wedge resection; 4. Invasive lung adenocarcinoma or lung malignancy other than lung adenocarcinoma diagnosed cytologically or pathologically; 5. Receiving lung cancer surgery before; 6. Receiving radiotherapy or chemotherapy.