Clinical Research Directory
Browse clinical research sites, groups, and studies.
Oxygen Extraction-guided Transfusion
Sponsor: Università degli Studi di Ferrara
Summary
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \< 7.0 g/dL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \[11\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.
Official title: Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
324
Start Date
2023-11-04
Completion Date
2027-01-01
Last Updated
2025-07-31
Healthy Volunteers
No
Conditions
Interventions
Individualized red blood cell transfusion strategy
Prescription of RCBT is restricted to patients who present Hb ≤ 9.0 g/dL and O2ER ≥ 30%.
European guidelines red blood cell transfusion strategy
RBCT according to ESICM guidelines
Locations (4)
Hospital Erasme
Brussels, Belgium
Università di Ferrara
Ferrara, Ferrara, Italy
Università di Perugia
Perugia, Italy, Italy
Anestesia e Rianimazione Cardio-Toraco-Vascolare
Siena, Italy