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RECRUITING

NCT06103331

Fungal Surveillance in Bangladesh

Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh

View on ClinicalTrials.gov

Summary

This will be an exploratory descriptive study designed to conduct surveillance for the identification of invasive fungal pathogens among hospitalized patients in Bangladesh at two tertiary care acute-level hospitals. including the Dhaka Medical College Hospital, the Dhaka Hospital of icddr,b, and the National Institute of Cancer Research Hospital (NICRH). Respiratory samples, blood, urine, cerebrospinal fluid, surgical wound infection swabs, and other samples including biopsy tissue specimens will be obtained at intensive care units, general medicine and surgery wards, post-operative care, etc. The collected specimens will be sent to the clinical microbiology laboratories of the surveillance hospitals or to the pathology laboratory (biopsy tissue specimens) to test for Aspergillus, Histoplasms, Candida, Pneumocystis, Cryptococcus, and Mucormycetes. The lab. methods will include microscopy, staining, culture, and biochemical tests mainly and if feasible then some specimens may undergo molecular or immunological methods.

Official title: Surveillance for Invasive Fungal Infections in Selected Hospitals in Dhaka City, Bangladesh

Key Details

Gender

All

Age Range

0 Months - Any

Study Type

OBSERVATIONAL

Enrollment

800

Start Date

2022-01-20

Completion Date

2026-09-30

Last Updated

2023-11-22

Healthy Volunteers

Conditions

Invasive Fungal Infections

Interventions

OTHER

Invasive Fungal disease surveillance

Management of invasive fungal infection according to pathogen identification and susceptibility report.

Inclusion Criteria: * Inclusion criteria: Must include all of the following criteria: 1. Admitted/hospitalized patients of any age and gender in tertiary-level acute care hospitals AND 2. Having any of the following co-morbid immunosuppressive conditions or risk factors for healthcare-associated fungal infections such as: * Chronic lung conditions including asthma, COPD * Hemodialysis patients, * diabetes, * Patients receiving chemotherapy or immunosuppressive drugs (e.g. corticosteroids, immunosuppressive drugs among organ transplant recipients), for ≥7 days * Patients with AIDS * Patients at risk of healthcare-associated infections (e.g., Patients under postoperative care, having a urinary catheter, with tracheal intubation, under ventilatory support, secured with intravenous (IV) cannula, any other invasive procedures, etc.) * Hospitalized Patients under prolonged injectable antibiotic treatment (\>7 days) * Prolonged hospitalization more than 7 days. * History of taking steroids or antibiotics for more than 2 weeks prior to hospitalization AND 3. Patients or caregivers providing consent For children aged \<5 years, the age criteria and additional inclusion criteria will be as follows: * 0 to 59-month-old children of either sex admitted in hospital with any illness. * Have features of sepsis/pneumonia (based on clinical features below) And any of the following criteria: * Those who will fail to respond to injectable antibiotics or both 1st and 2nd line antibiotics (1st line- inj. Ampicillin plus gentamicin, 2nd line- inj. Ceftriaxone plus levofloxacin/gentamicin as per icddr,b hospital protocol) * Any child with SAM or h/o recent measles or any condition that may induce immune suppression plus fail to respond to injectable antibiotics/ 1st line antibiotics (1st line antibiotics- inj. Ampicillin +inj. Gentamicin) * Those who will develop late-onset hospital-associated infection (LOHAI) * Any child who will require ICU care for more than 7 days * Develop extensive thrush after taking long-term injectable antibiotics * History of taking steroids or antibiotics for more than 2 weeks prior to hospitalization Exclusion Criteria: * History of taking antifungal drugs within 2 weeks * Not willing to give consent

Locations (1)

International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

Dhaka, Bangladesh