Clinical Research Directory

Inclusion Criteria: * Adult subject (\>18 years old) affected by partial Dunnigan lipodystrophy in the homozygous or heterozygous state (genetic search for the positive mutation carried out before inclusion in the study). * Person affiliated to or beneficiary of a social security scheme. * Free, informed and written consent signed by the participant and the investigator. Exclusion Criteria: * \- Minor * Persons placed under judicial protection, person participating in another research including a period of exclusion still in progress, severely impaired physical and/or psychological health, which, according to the investigator, may affect the participant's compliance with the study * Previous known diabetes * Pregnant woman * Woman who gave birth less than 6 months ago * Breastfeeding in progress * Participation in other research that may have an impact on the evaluation of the main judgment criteria * Hemoglobin b level \< 7 mg/dl or \< 9-10 mg/dl for patients with cardiovascular or respiratory pathology. * Proven inflammatory pathologies * Anti-inflammatory treatment: taking corticosteroids in the last 3 months. * Active smoking