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Cerebellar Modulation of Cognition in Psychosis
Sponsor: Mclean Hospital
Summary
The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain activity. Forms of TMS are FDA-approved to treat depression and obsessive compulsive disorder. In this study, we will use a different form of TMS to temporarily change brain activity to observe how that changes speed in problem-solving.
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
95
Start Date
2024-07-31
Completion Date
2029-12
Last Updated
2026-03-17
Healthy Volunteers
No
Interventions
intermittant theta burst stimulation (iTBS)
iTBS consists of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses.
continuous theta burst stimulation (cTBS)
cTBS consists of 3 pulses at 50 Hz repeated at 5 Hz (every 200ms) continuously for a total of 600 pulses
sham rTMS
sham rTMS does not deliver a significant change in magnetic field strength
Locations (2)
McLean Hospital
Belmont, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States