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RECRUITING
NCT06107764
NA

Cerebellar Modulation of Cognition in Psychosis

Sponsor: Mclean Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain activity. Forms of TMS are FDA-approved to treat depression and obsessive compulsive disorder. In this study, we will use a different form of TMS to temporarily change brain activity to observe how that changes speed in problem-solving.

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

95

Start Date

2024-07-31

Completion Date

2029-12

Last Updated

2026-03-17

Healthy Volunteers

No

Interventions

DEVICE

intermittant theta burst stimulation (iTBS)

iTBS consists of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses.

DEVICE

continuous theta burst stimulation (cTBS)

cTBS consists of 3 pulses at 50 Hz repeated at 5 Hz (every 200ms) continuously for a total of 600 pulses

DEVICE

sham rTMS

sham rTMS does not deliver a significant change in magnetic field strength

Locations (2)

McLean Hospital

Belmont, Massachusetts, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States