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Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
Sponsor: Columbia University
Summary
The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.
Official title: Adaptive Radiotherapy Based on Multi-Parametric Diffusion- and Perfusion-weighted Magnetic Resonance Imaging in Patients With Newly Diagnosed High-Grade Glioma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-01-30
Completion Date
2027-12
Last Updated
2025-07-03
Healthy Volunteers
No
Interventions
Adaptive Radiotherapy
Each patient will undergo a brain MRI at the following time points: 1. Baseline- within 2 weeks prior to the start of chemo-RT, 2. Week #1- on Fractions # 4 or 5 3. Week #2- between Fractions # 6-10 (at least 5 days after the Week 1 MRI) 4. Week #3- between Fractions # 11-15 (at least 5 days after the Week 2 MRI) 5. Week #4- between Fractions # 16-20 gadolinium contrast (at least 5 days after the Week 3 MRI) 6. Week #5- on Fractions # 24 or 25 (after the start of the Conedown) 7. Week #6- +/- 3 days of Fraction #30 (end of RT) Patients receiving hypofractionated radiotherapy will undergo a brain MRI at the following time points: 1. Baseline- within 2 weeks prior to the start of your standard of care chemotherapy radiation treatment (chemo-RT), 2. Week #1 - on Fractions #4 or 5 3. Week #2 - between Fractions #6-10 (at least 5 days after the Week 1 MRI) 4. Week #3 - between Fractions #11-15 (at least 5 days after the Week 2 MRI)
Locations (1)
Columbia University Irving Medical Center/NYPH
New York, New York, United States