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A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Sponsor: Eli Lilly and Company
Summary
The main purpose of this study is to determine the safety and efficacy of orforglipron. Participants will have Type 2 Diabetes (T2D) and have inadequate glycemic control with insulin glargine with or without metformin and/or SGLT-2 (sodium-glucose cotransporter-2) inhibitor. The study will last about 46 weeks and may include up to 20 visits.
Official title: A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
546
Start Date
2023-11-10
Completion Date
2025-09-15
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
Orforglipron
Administered orally.
Placebo
Administered orally.
Locations (70)
MD First Research - Chandler
Chandler, Arizona, United States
Phoenix Clinical LLC
Phoenix, Arizona, United States
SanRo Clinical Research Group
Bryant, Arkansas, United States
Velocity Clinical Research, Gardena
Gardena, California, United States
Loma Linda University Health System
Loma Linda, California, United States
Western University of Health Sciences
Pomona, California, United States
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
Toluca Lake, California, United States
CMR of Greater New Haven, LLC
Hamden, Connecticut, United States
Care Access - Brandon
Brandon, Florida, United States
Encore Medical Research
Hollywood, Florida, United States
Encore Medical Research - Weston
Weston, Florida, United States
Orita Clinical Research
Decatur, Georgia, United States
Bingham Memorial Hospital
Blackfoot, Idaho, United States
St. Luke's Humphreys Diabetes Center: Boise
Boise, Idaho, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
The Research Group of Lexington
Lexington, Kentucky, United States
Clinvest Headlands Llc
Springfield, Missouri, United States
Richmond University Medical Center
Staten Island, New York, United States
Velocity Clinical Research, Mt. Auburn
Cincinnati, Ohio, United States
Velocity Clinical Research, Medford
Medford, Oregon, United States
Tristar Clinical Investigations
Philadelphia, Pennsylvania, United States
Frontier Clinical Research, LLC
Scottdale, Pennsylvania, United States
Lifedoc Research - Lenox Park Drive
Memphis, Tennessee, United States
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Texas Valley Clinical Research
Weslaco, Texas, United States
CEDOES
Vitória, Espírito Santo, Brazil
L2IP - Instituto de Pesquisas Clínicas
Brasília, Federal District, Brazil
Quanta Diagnóstico e Terapia
Curitiba, Paraná, Brazil
Insight Centro de Pesquisas
Porto Alegre, Rio Grande do Sul, Brazil
Centro de Pesquisa Sao Lucas
Campinas, São Paulo, Brazil
Centro Multidisciplinar de Estudos Clinicos
São Bernardo do Campo, São Paulo, Brazil
ISPEM - Instituto São José dos Campos em Pesquisas Médicas
São José dos Campos, São Paulo, Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, Brazil
CPQuali Pesquisa Clínica
São Paulo, Brazil
The Second People's Hospital of Hefei
Hefei, Anhui, China
Wannan Medical College Yijishan Hospital
Wuhu, Anhui, China
Beijing Hospital
Beijing, Beijing Municipality, China
Chongqing General Hospital
Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, Henan, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Nanjing First Hospital
Nanjing, Jiangsu, China
Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, China
Jinan Central Hospital
Jinan, Shandong, China
Tokuyama Clinic
Mihama-ku,Chiba City, Chiba, Japan
Hasegawa Medical Clinic
Chitose, Hokkaido, Japan
MinamiAkatsukaClinic
Mito, Ibaraki, Japan
Matoba Internal Medicine Clinic
Ebina, Kanagawa, Japan
Takai Internal Medicine Clinic
Kamakura-shi, Kanagawa, Japan
Shiraiwa Medical Clinic
Kashihara, Osaka, Japan
The Institute of Medical Science, Asahi Life Foundation
Chuo-ku, Tokyo, Japan
Tokyo-Eki Center-building Clinic
Chuo-ku, Tokyo, Japan
Fukuwa Clinic
Chuo-ku, Tokyo, Japan
Medical Corporation Sato Medical clinic
Ootaku, Tokyo, Japan
Tama Center Clinic Mirai
Tama, Tokyo, Japan
Jinnouchi Hospital
Kumamoto, Japan
Kansai Electric Power Hospital
Osaka, Japan
Abe Clinic
Ōita, Japan
Centro de Endocrinologia y Nutricion
Caguas, Puerto Rico
FDI Clinical Research
San Juan, Puerto Rico
Diabdana
Oradea, Bihor County, Romania
C.M.D.T.A. Neomed
Brasov, Brașov County, Romania
Geea Medical Easy Diet
Bucharest, Bucharest, Romania
Centrul Medical NutriLife
Bucharest, Bucharest, Romania
Centrul Medical Endocrinologie si Diabet Dr. Paveliu
Bucharest, Bucharest, Romania
CMI DNBM Dr. Pop Lavinia
Baia Mare, Maramureş, Romania
SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureş, Mureș County, Romania
Milena Sante
Galați, Romania
Diamed Obesity
Galați, Romania
Clinica Korall
Satu Mare, Romania