Clinical Research Directory

Inclusion Criteria: 1. Aged ≥ 18 years or more; 2. acute ischemic stroke within 24 hours from onset to randomization; 3. NIHSS ≥6 points before randomization; 4. Internal carotid artery, or the middle cerebral artery M1 or M2 occlusion confirmed by CTA/MRA/DSA; 5. Baseline ASPECTS score ≥ 3 and ≤8, or cerebral infarction core volume \< 100ml; 6. The patient decides to undergo endovascular therapy; 7. The patient or patient's representative signs a written informed consent form. Exclusion Criteria: 1. CT or MR evidence of hemorrhage; 2. Currently pregnant or lactating (women patients); 3. Allergy to radiographic contrast agents, or nitinol devices; 4. Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel; 5. Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation); 6. Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations; 7. Previous bleeding disorders, severe heart, liver or kidney disease, or sepsis; 8. Brain tumors with mass effect (except meningiomas) that are radiographically pleasant; 9. Intracranial aneurysm, arteriovenous malformation; 10. Any terminal illness with life expectancy less than 6 months; 11. Participating in other clinical trials.