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Reversibility of Bronchial Obstruction in Children Born Preterm
Sponsor: Charles University, Czech Republic
Summary
This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry. All children were diagnosed with Chronic Lung Disease of Immaturity (CLDI). The main questions are: * Is any inhaled bronchodilator or their combination generally superior in children with CLDI when assessing the reversibility of bronchial obstruction? * Is there an individual difference in the effect of betamimetic, anticholinergic or their combination between children with CLDI? Participants will: * Come to our clinic in a stable state without acute infection and they will be randomly assigned to the first inhaled bronchodilator. * They will then perform a spirometry test before and after the inhalation of the drug. * This visit will repeat 3 times, each with a different bronchodilator (beta2agonist, anticholinergic and their combination).
Official title: Bronchodilator Response To Inhaled Beta-2 Agonist and Anticholinergic Drugs in Children Born Preterm
Key Details
Gender
All
Age Range
5 Years - 18 Years
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2021-04-01
Completion Date
2026-01-01
Last Updated
2025-05-22
Healthy Volunteers
No
Conditions
Locations (1)
First faculty of Medicine, Charles university.
Prague, Czechia