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RECRUITING
NCT06111105

GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer

Sponsor: Claus Lindbjerg Andersen

View on ClinicalTrials.gov

Summary

Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough. There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points. The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. GUIDE.MRD-01-CRC is a part of the GUIDE.MRD project.

Official title: GUIding Multi-moDal ThErapies Against MRD by Liquid Biopsies in Colorectal Cancer - GUIDE.MRD-01-CRC

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

590

Start Date

2023-08-01

Completion Date

2031-07-31

Last Updated

2025-03-30

Healthy Volunteers

No

Locations (15)

Abteilung für Onkologie, Medizinische Universität Graz

Graz, Styria, Austria

Ordenskrankenhaus Graz Mitte

Graz, Styria, Austria

Bispebjerg Hospital

Copenhagen, Capital Region of Denmark, Denmark

Herlev Hospital

Herlev, Capital Region of Denmark, Denmark

Aarhus University Hospital

Aarhus, Central Jutland, Denmark

Gødstrup Hospital

Herning, Central Jutland, Denmark

Regional Hospital Horsens

Horsens, Central Jutland, Denmark

Regional Hospital Randers

Randers, Central Jutland, Denmark

Regional Hospital Viborg

Viborg, Central Jutland, Denmark

Aalborg University Hospital

Aalborg, North Denmark, Denmark

Odense University Hospital

Odense, The Region of Southern Denmark, Denmark

LCCRH (Laboratoire Cellules Circulantes Rares Humaines) - CHU de Montpellier

Montpellier, France

Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf

Hamburg, Hamburg, Germany

Universitätsklinikum Hamburg-Eppendorf

Hamburg, Hamburg, Germany

Karolinska University Hospital

Huddinge, Stockholm County, Sweden