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GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer
Sponsor: Claus Lindbjerg Andersen
Summary
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough. There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points. The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. GUIDE.MRD-01-CRC is a part of the GUIDE.MRD project.
Official title: GUIding Multi-moDal ThErapies Against MRD by Liquid Biopsies in Colorectal Cancer - GUIDE.MRD-01-CRC
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
590
Start Date
2023-08-01
Completion Date
2031-07-31
Last Updated
2025-03-30
Healthy Volunteers
No
Locations (15)
Abteilung für Onkologie, Medizinische Universität Graz
Graz, Styria, Austria
Ordenskrankenhaus Graz Mitte
Graz, Styria, Austria
Bispebjerg Hospital
Copenhagen, Capital Region of Denmark, Denmark
Herlev Hospital
Herlev, Capital Region of Denmark, Denmark
Aarhus University Hospital
Aarhus, Central Jutland, Denmark
Gødstrup Hospital
Herning, Central Jutland, Denmark
Regional Hospital Horsens
Horsens, Central Jutland, Denmark
Regional Hospital Randers
Randers, Central Jutland, Denmark
Regional Hospital Viborg
Viborg, Central Jutland, Denmark
Aalborg University Hospital
Aalborg, North Denmark, Denmark
Odense University Hospital
Odense, The Region of Southern Denmark, Denmark
LCCRH (Laboratoire Cellules Circulantes Rares Humaines) - CHU de Montpellier
Montpellier, France
Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
Hamburg, Hamburg, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Hamburg, Germany
Karolinska University Hospital
Huddinge, Stockholm County, Sweden