Clinical Research Directory

Inclusion Criteria: * Chronic limb-threatening ischemia-Patients with chronic leg pain for at least 6 months with intensity (VAS \>=5) * those who (only if a signature was obtainable), or whose legal guardian,fully understood the clinical trial -details and signed the informed consent form Exclusion Criteria: * Chronic Venous Insufficiency * women with positive a pregnancy tests before the trial or who planned to become pregnant within the following 3 years * other patients viewed as inappropriate by the staff * disagreement with participation in the study