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Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery
Sponsor: St. Antonius Hospital
Summary
Changes in host gene expression may provide additional information to diagnose postoperative infection and improve outcome after surgery. This study aims to validate the early diagnostic performance of specific gene signatures for differentiating infection from non-infected SIRS or uncomplicated postoperative course in blood sampes of adult patients undergoing major noncardiac surgery.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2024-12-01
Completion Date
2026-06-01
Last Updated
2024-12-16
Healthy Volunteers
No
Conditions
Interventions
blood leucocyte transcriptomics
the analysis of the RNA transcripts produced by the genotype at a given time that provides a link between the genome, the proteome, and the cellular phenotype.
Locations (2)
Amphia hospital
Breda, Netherlands
St Antonius hospital
Nieuwegein, Netherlands