Clinical Research Directory

Inclusion Criteria: * Women ages 25-40 * Woman who meet criteria for POI defined as AFC \< 5, AMH \< 3 pmol/L and FSH \>30 IU/L. There may also be associated symptoms of the menopause such as hot flushes, night sweats, insomnia and vaginal dryness. * Women who are not taking any other medical or fertility treatments except natural estrogen to stop hot flushes. * Those who are provided with informed consent. Exclusion Criteria: * Women with age \> 40 * Women with history of autoimmune disorders * Women with a history of hematopoietic cell malignancies * Women with sickle cell disease * Women with any other comorbidities that would preclude infertility treatment and pregnancy such as HIV/AIDS, hepatitis B or C, breast cancer or body mass index (BMI) \>40.