Clinical Research Directory
Browse clinical research sites, groups, and studies.
Phase 2 Study of TTX-030 and Chemotherapy With or Without Budigalimab for 1L mPDAC Patients
Sponsor: Trishula Therapeutics, Inc.
Summary
This is a Phase 2, multicenter, open-label, 3-arm, randomized, parallel group study to evaluate the efficacy and safety of TTX-030 with or without budigalimab in combination with chemotherapy (gemcitabine + nab-paclitaxel) in subjects with metastatic PDAC who did not have prior treatment for metastatic disease and are eligible to receive gemcitabine and nab-paclitaxel chemotherapy as SOC.
Official title: An Open-Label Multicenter 3-Arm Randomized Phase 2 Study to Assess the Efficacy and Safety of TTX-030 and Chemotherapy With or Without Budigalimab, Compared to Chemotherapy Alone, for the Treatment of Patients Not Previously Treated for Metastatic Pancreatic Adenocarcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
194
Start Date
2024-03-25
Completion Date
2027-06
Last Updated
2024-12-04
Healthy Volunteers
No
Conditions
Interventions
TTX-030, nab-paclitaxel and gemcitabine
Dose and schedule per protocol
TTX-030, budigalimab, nab-paclitaxel and gemcitabine
Dose and schedule per protocol
Nab-Paclitaxel and gemcitabine
Dose and schedule per protocol
Locations (64)
Investigative Site
Tucson, Arizona, United States
Investigative SIte
Hot Springs, Arkansas, United States
Investigative Site
Bakersfield, California, United States
Investigative Site
Fullerton, California, United States
Investigative Site
Los Angeles, California, United States
Investigative Site
Denver, Colorado, United States
Investigative Site
St. Petersburg, Florida, United States
Investigative Site
West Palm Beach, Florida, United States
Investigative Site
Atlanta, Georgia, United States
Investigative Site
Wichita, Kansas, United States
Investigative Site
Baton Rouge, Louisiana, United States
Investigative Site
Columbia, Maryland, United States
Investigative Site
Burnsville, Minnesota, United States
Investigative Site
Las Vegas, Nevada, United States
Investigative Site
Florham Park, New Jersey, United States
Investigative Site
Asheville, North Carolina, United States
Investigative Site
Columbus, Ohio, United States
Investigative Site
Eugene, Oregon, United States
Investigative Site
Portland, Oregon, United States
Investigative Site
Horsham, Pennsylvania, United States
Investigative Site
Austin, Texas, United States
Investigative Site
Dallas, Texas, United States
Investigative Site
San Antonio, Texas, United States
Investigative Site
Tyler, Texas, United States
Investigative Site
Arlington, Virginia, United States
Investigative Site
Norfolk, Virginia, United States
Investigative Site
Roanoke, Virginia, United States
Investigative Site
Milwaukee, Wisconsin, United States
Investigative Site
Albury, New South Wales, Australia
Investigative Site
Westmead, New South Wales, Australia
Investigative Site
Herston, Queensland, Australia
Investigative Site
Besançon, France
Investigative Site
Dijon, France
Investigative Site
Lille, France
Investigative Site
Paris, France
Investigative Site
Poitiers, France
Investigative Site
Genova, Italy
Investigative Site
Meldola, Italy
Investigative Site
Milan, Italy
Investigative Site
Pavia, Italy
Investigative Site
Puglia, Italy
Investigative Site
Verona, Italy
Investigative Site
Goyang-si, South Korea
Investigative Site
Seongam, South Korea
Investigative Site
Seongnam-si, South Korea
Investigative Site
Seoul, South Korea
Investigative Site
Seoul, South Korea
Investigative Site
Seoul, South Korea
Investigative Site
Seoul, South Korea
Investigative Site
Seoul, South Korea
Investigative Site
Barcelona, Spain
Investigative Site
Barcelona, Spain
Investigative Site
Madrid, Spain
Investigative Site
Madrid, Spain
Investigative Site
Madrid, Spain
Investigative Site
Majadahonda, Spain
Investigative Site
Pamplona, Spain
Investigative Site
Valencia, Spain
Investigative Site
Zaragoza, Spain
Investigative Site
Kaohsiung City, Taiwan
Investigative Site
Taichung, Taiwan
Investigative Site
Tainan, Taiwan
Investigative Site
Taipei, Taiwan
Investigative Site
Taoyuan District, Taiwan