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The Swedish BioFINDER - Primary Care Study
Sponsor: Skane University Hospital
Summary
The overall aim of the study is to improve the diagnostic accuracy of AD and cognitive impairment in primary care settings to ensure better care and treatment as well as facilitate correct referrals to specialized memory clinics. The investigators will strive to recruit diverse and representative populations of patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and mild dementia. The specific aims of the study are to: 1. Improve the detection of mild cognitive impairment (MCI) and dementia in primary care. 2. Develop and evaluate cognitive tests, blood-based biomarkers and brain imaging methods that are suitable for accurate and early diagnosis of Alzheimer's disease (AD) in primary care. 3. To prospectively validate plasma AD biomarkers for diagnosis of patients with cognitive symptoms who are evaluated in primary care. 4. Determine whether blood AD biomarkers improve patient management in primary care.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2020-01-01
Completion Date
2028-12-31
Last Updated
2026-04-06
Healthy Volunteers
No
Conditions
Interventions
Plasma APS 2 score
APS 2 score (combination of ptau217/nptau217 and Ab42/Ab40). The cut off will be predefined. The samples will be analysed prospectively every two weeks.
Plasma p-tau217/np-tau217
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
Plasma p-tau217
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
Plasma neurofilament light (NfL)
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
Plasma Ab42/Ab40
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
MRI and CT of the brain
Structural brain imaging
Different cognitive tests
Both standard paper-and-pen tests as well as digital cognitive tests will be evaluated.
Locations (1)
Primary care centers in Region Skåne
Malmo, Sweden