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RECRUITING

NCT06121219

Effect of Visual Retraining After Stroke

Sponsor: University of Rochester

View on ClinicalTrials.gov

Summary

This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.

Official title: Effect of Visual Retraining on Visual Loss Following Cortical Damage

Key Details

Gender

All

Age Range

21 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2024-09-05

Completion Date

2032-01

Last Updated

2025-07-16

Healthy Volunteers

Yes

Conditions

Vision Loss Partial Vision; Loss, Both Eyes Hemianopia Homonymous Hemianopia Quadrantanopia Stroke, Ischemic Stroke - Occipital Infarction Cortical Blindness

Interventions

DEVICE

Training in the Blind Field

A computer software and chin-rest necessary to perform visual training will be loaned to each subject to be used at home. Subjects will perform one to two daily training sessions in their home, consisting of 200-300 trials each. The visual task performed repetitively will involve discriminating the direction of motion, the presence of motion, or the orientation of a visual stimulus (either a small cloud of dots or bars) located at a predetermined location in the blind field. The computer program will automatically create a record of patient performance during each home training session. Subjects will train daily (about 40-60 minutes total), 5 to 7 days per week for at least 3 and up to 12 months at a time.

Cortically Blind Subjects Inclusion: * Between 21 and 80 years of age * Residents of the United States or Canada * Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years) * Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus. * Able to fixate on visual targets reliably for 1000ms * Must have a home computer (desktop or laptop) and reliable internet access * Willing, able, and competent to provide informed consent * Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months. Exclusion: * Past or present eye disease interfering with visual acuity * BCVA worse than 20/40 in either eye * Damage to the dorsal Lateral Geniculate Nucleus * Diffuse whole brain degenerative processes * History of traumatic brain injury * Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures * Documented history of drug/alcohol abuse * Currently taking neuroactive medications which would impact training, as determined by PI * Presence of cognitive or seizure disorders * One-sided attentional neglect * Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed. Control Subjects (n = 50) Inclusion: * Between 21 and 80 years of age * Report no history of neurological disorder. * Competent and responsible, as determined by the Principal Investigator. Exclusion: * Presence of damage to the visual system * Presence of an active disease process involving their nervous system. * Cognitive or seizure disorders * Best corrected visual acuity worse than 20/40 in either eye * Presence of vision field loss from ocular disease or disorder

Locations (1)

University of Rochester Medical Center

Rochester, New York, United States