Clinical Research Directory

Inclusion Criteria: 1. any sex 2. age between 18 and 50 years 3. OCT1 wild type: homozygous for OCT1\*1 OCT "poor transporter": homozygous or heterozygous for OCT1\*3, \*4, \*5, \*6 4. understands the study purpose and design 5. contractually capable and provides signed informed consent form 6. healthy condition or mild and/or well-treated forms of allergies, asthma, hypertension, and orthopedic diseases 7. a maximum of 3 chronically taken drugs not interfering with OCT1 activity Exclusion Criteria: 1. BMI \> 32 kg/m2 and \< 17 kg/m2 2. body weight \< 48 kg 3. known pregnancy or lactation period 4. women: positive urine pregnancy test at screening or kinetic visit 1 of each arm 5. men: hemoglobin \< 13 g/dl (8,07 mmol/l) women: hemoglobin \< 12 g/dl (7,45 mmol/l) 6. elevated liver function tests (1 or more of ALAT, ASAT, yGT, Bilirubin \> 2x ULN) 7. reduced renal function (eGFRMDRD \< 60 ml/min/1,7 m2) 8. QTcF \> 450 ms in screening ECG 9. psychiatric disease requiring recent or actual treatment 10. drug dependency at the time of visit 11. use of recreational drugs more than twice a week 12. any known hypersensitivity or allergic reactions to thiamin 13. history of severe hypersensitivity reactions and/or anaphylaxis 14. clinically proven vitamin B1 deficiency 15. individuals taking regular vitamin B1 or multi-vitamin supplements who are not willing to comply with a 48-hour washout of these supplements before each kinetic visit 16. individuals who have taken vitamin B supplements or multi-vitamins in the past 2 days before kinetic visit 1 of each arm 17. poor venous conditions that make it impossible to place a peripheral venous catheter and regularly draw blood through it