Clinical Research Directory

Inclusion Criteria: 1. Age \> 18 years old, male and female; 2. According to the Guidelines for the Diagnosis and Treatment of Primary Lung Cancer (2022 edition), the patient was diagnosed with NSCLC by imaging and histopathology; 3. TNM stages were III-IV; 4. Newly diagnosed, first-line treatment failure, refusal or inability to perform conventional treatment (surgery, chemoradiotherapy); 5. ECOG PS ≤2; 6. Expected survival \> 3 months; 7. Sign the informed consent voluntarily, and the compliance is good. Exclusion Criteria: 1. Previously received interventional therapy (iodine particle implantation, ablation, TACE treatment); 2. Combined with extensive and uncontrolled extrapulmonary metastases, such as liver metastasis, bone metastasis, and brain metastasis; 3. Have had or currently having other primary malignant tumors; 4. White blood cell \< 3×109/L, platelet count \< 50×109/L, HGB \< 90 g/L; 5. Hepatic and renal insufficiency (creatinine \> 2 mg/L; AST and/or ALT \> 2 times the normal upper limit); 6. Coagulation dysfunction (INR \> 1.5) or known bleeding disease (except lung cancer combined with hemoptysis), or anticoagulation therapy; 7. Patients with active infection requiring antibiotic treatment; 8. Uncontrolled hypertension, diabetes, and cardiovascular disease with obvious symptoms; 9. contrast agent allergy; 10. Women with pregnancy or lactation.