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Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)
Sponsor: International Vaccine Institute
Summary
This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations to estimate the incidence of persistent HPV infection among sexually active young women. The data to fulfill the objectives will be collected through a series of Cross-Sectional Surveys (CSS) and Longitudinal Studies (LS) in all 8 countries 3 South Asian countries including Bangladesh, Pakistan, Nepal and 5 sub-Saharan African countries including Sierra Leone, Tanzania, Ghana, Zambia and DR Congo. Qualitative sub-studies (QS) will be conducted in selected countries and populations following the CSS to further understand and unpack risk factors for HPV infection as well as to explore how gender-related dynamics including perceptions of gender norms and stigma, influence HPV burden and/or create barriers that shape girls/women access to and uptake of HPV prevention, screening, and treatment services. Specific study protocols and corresponding ethical applications for the qualitative sub-studies will be developed separately.
Key Details
Gender
FEMALE
Age Range
9 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
29750
Start Date
2023-11-23
Completion Date
2027-12
Last Updated
2025-07-16
Healthy Volunteers
Yes
Conditions
Interventions
Urine Sample Collection
When urine is collected as a sample in either CSS or LS, first flow urine samples will be collected
Self-collected Vaginal Swab
Self-collected Vaginal Swab will be collected by the participant under the supervision of a trained nurse or other health care worker.
Blood Samples
If funding permits, a blood sample may be collected from participants in LS once during the follow-up period. If blood sample collection was not feasible during a visit, two additional attempts may be made to collect blood samples from LS participants during the subsequent follow-up visits.
Locations (8)
Diarrhoeal Disease Research, Bangladesh (icddr,b)
Dhaka, Bangladesh
Institut National pour la Recherche Biomedicale (INRB)
Kinshasa, Democratic Republic of the Congo
University of Health and Allied Sciences (UHAS)
Ho, Volta Region, Ghana
Dhulikhel Hospital Kathmandu University Hospital (DHKUH)
Dhulikhel, Nepal
Aga Khan University (AKU)
Karachi, Pakistan
College of Medicine and Allied Health Sciences (COMAHS)
Freetown, Sierra Leone
Mwanza Intervention Trial Unit (MITU)
Mwanza, Tanzania
ZAMBART
Lusaka, Zambia