Clinical Research Directory

Inclusion Criteria: * The study will recruit patient participants presenting for periodontal treatment within the National Dental PBRN practices participating in this study. To be eligible to participate in this study, a potential patient participant must meet all the following criteria: * Adult who is at least 35 years old. * Presence of ≥ 15 permanent teeth excluding 3rd molars. * In good general health as evidenced by medical history (ASA Class I or II) per the practitioner. * Planned to receive periodontal care for Generalized Periodontitis and a minimum of two quadrants of SRP (CDT code 4341) in practices participating in the National Dental PBRN. * Willing to comply with all study visits and be available for the duration of the study (12-15 months) * Willing to provide contact information for self, including a cellular phone number for study text, and one to two emergency contacts to be reached for the follow-up visits and any other study-related matters for the duration of the study. Exclusion Criteria: * Known drug allergy to any antibiotics or anesthetics. * Use of systemic antibiotics taken within the previous 3 months prior to enrollment. * Medical condition which requires antibiotic prophylaxis prior to dental treatments/visits. * Current use of medications that, in the opinion of the practitioner, may cause adverse effects with AMXM (such as disulfiram, warfarin, and oral contraceptives). * History of any periodontal therapy (including SRP D4341, D4342) within the last 6 months prior to enrollment. * Is currently pregnant or lactating per patient participant self-report. * Is considered immunocompromised, in the opinion of the practitioner (including diseases and conditions such as HIV/AIDS, immunosuppressive drug therapy and/or radiation), or has chronic mucosal lesions (e.g. pemphigus vulgaris) affecting the gingiva. * Has Diabetes mellitus with an HbA1c score of \>/= 10% within the past 3 months as per patient participant self-report.