Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06133114
PHASE4

Psychopharmacological Treatment of Emotional Distress

Sponsor: Icahn School of Medicine at Mount Sinai

View on ClinicalTrials.gov

Summary

This is an inpatient four-arm randomized control trial comparing single drug clonazepam (S arm), a two-drug combination clonazepam/olanzapine (D arm), and a three-drug combination clonazepam/olanzapine/buprenorphine (T arm) with treatment as usual (TAU arm) in the treatment of emotional distress, specifically the Suicide Crisis Syndrome (SCS). All participants in experimental arms receive 2-day pulse treatments targeting four out of five of the acute emotional distress symptoms. The primary outcome measure is SCS at discharge and one-month follow-up. The secondary outcome measures include questions about suicidal behaviors associated with emotional distress at a one-month follow-up.

Official title: Psychopharmacological Treatment of Emotional Distress: A Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2024-03-13

Completion Date

2026-10

Last Updated

2024-06-07

Healthy Volunteers

No

Interventions

DRUG

Clonazepam

0.5 mg twice a day (1 mg a day)

DRUG

Olanzapine

2.5 mg once a day of Olanzapine

DRUG

Buprenorphine

2 mg once a day of Buprenorphine

Locations (1)

Icahn School of Medicine at Mount Sinai

New York, New York, United States