Clinical Research Directory

Inclusion Criteria: * Patient aged 18 and over * Hospitalized patient with ischemic stroke in the deep territory of the middle cerebral artery * Patient with lesion observable on MRI * Patient included between 24 hours and 7 days after the ischemic stroke * Patient with a temporal window which allows soundproofing of the polygon of Willis and the middle cerebral artery * Patient having signed free, informed and written consent * Patient affiliated to a social security system (excluding AME) Exclusion Criteria: * Contralateral middle cerebral artery territory stroke or contralateral middle cerebral artery occlusion * Patient with contraindication to Doppler ultrasound with contrast (right-left shunt, severe pulmonary arterial hypertension) * Patient with hypersensitivity to the active princip of Sonovue (sulfur hexafluoride) or these excipients * Patient with uncontrolled systemic hypertension * Patient with respiratory distress syndrome * Patient under guardianship or curatorship * Pregnant or breastfeeding patient (positive blood pregnancy test during hospitalization) * Patient with damaged skin at the temporal level * Patient having presented in the 7 days preceding inclusion an acute coronary syndrome or suffering from unstable ischemic heart disease