Clinical Research Directory

Inclusion Criteria: The inclusion criteria are as follows: Patients hospitalized in the adult intensive care unit of the Fundación Santa Fe de Bogotá. Requirement of invasive mechanical ventilation through an endotracheal tube for a period exceeding 72 hours with an expected continuation of at least 24 hours. Barthel Index equal to or greater than 70 Exclusion Criteria: * Invasive mechanical ventilation through tracheostomy or a nasotracheal tube. * History of head and neck surgery at any time prior to ICU admission. * Patients directly admitted to the ICU due to cardiac arrest by any cause. * Airway burn. * Burns involving ≥ 50% of the body surface area. * Chronic obstructive pulmonary disease (these patients usually require prolonged mechanical ventilation due to the underlying respiratory dysfunction) * Patients referred from another institution. * Demyelinating diseases or neuromuscular junction disorders at ICU admission. * Patients requiring neuromuscular blockade. * Patients with a life expectancy of ≤180 days will be excluded based on their primary diagnosis (e.g., advanced cancer, end-stage heart failure), comorbidities, recent clinical course, medical judgment by the ICU team, and functional status as assessed by the Barthel index. * ICU readmissions. * Participation in other rehabilitation clinical trials. * Liver or kidney transplant. * Patients with an active cancer diagnosis undergoing oncological treatment (chemotherapy/surgery) at the time of eligibil- ity assessment.