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RECRUITING
NCT06136624
PHASE3

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall survival (OS) in participants with mCRPC previously treated with next-generation hormonal agent (NHA) and taxane-based chemotherapy. It is hypothesized that opevesostat is superior with respect to OS in androgen receptor ligand binding domain (AR LBD) mutation-negative and -positive participants.

Official title: A Phase 3 Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Previously Treated With Next-generation Hormonal Agent (NHA) and Taxane-based Chemotherapy (OMAHA-003)

Key Details

Gender

All

Age Range

Any - Any

Study Type

INTERVENTIONAL

Enrollment

1310

Start Date

2023-12-31

Completion Date

2028-08-02

Last Updated

2026-04-08

Healthy Volunteers

No

Interventions

DRUG

Opevesostat

Administered orally

DRUG

Abiraterone acetate

Administered orally

DRUG

Enzalutamide

Administered orally

DRUG

Hydrocortisone

Administered orally or IM as a rescue medication

DRUG

Fludrocortisone acetate

Administered orally

DRUG

Prednisone

Administered orally

DRUG

Dexamethasone

Administered orally as rescue medication

Locations (282)

University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040)

Orange, California, United States

Stanford Cancer Center ( Site 0036)

Palo Alto, California, United States

Kaiser Permanente Riverside Medical Center ( Site 0099)

Riverside, California, United States

Anschutz Cancer Pavilion ( Site 0046)

Aurora, Colorado, United States

University of Colorado Health - Highlands Ranch Hospital ( Site 0111)

Highlands Ranch, Colorado, United States

Colorado Clinical Research ( Site 0067)

Lakewood, Colorado, United States

University of Colorado Health - Lone Tree Medical Center ( Site 0112)

Lone Tree, Colorado, United States

Yale-New Haven Hospital-Yale Cancer Center ( Site 0064)

New Haven, Connecticut, United States

Florida Cancer Specialists - South ( Site 7003)

Fort Myers, Florida, United States

Bruce W. Carter Veterans Affairs Medical Center ( Site 0082)

Miami, Florida, United States

University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051)

Miami, Florida, United States

University of Illinois at Chicago ( Site 0105)

Chicago, Illinois, United States

University of Chicago Medical Center ( Site 0045)

Chicago, Illinois, United States

University of Iowa ( Site 0047)

Iowa City, Iowa, United States

University of Kentucky Chandler Medical Center ( Site 0048)

Lexington, Kentucky, United States

Ochsner Clinic Foundation ( Site 0108)

New Orleans, Louisiana, United States

Baltimore Veterans Affairs Medical Center ( Site 0069)

Baltimore, Maryland, United States

Greenebaum Comprehensive Cancer Center ( Site 0049)

Baltimore, Maryland, United States

Henry Ford Hospital ( Site 0015)

Detroit, Michigan, United States

M Health Fairview Clinics and Surgery Center ( Site 0019)

Minneapolis, Minnesota, United States

Metro-Minnesota Community Clinical Oncology ( Site 0014)

Saint Louis Park, Minnesota, United States

Washington University School of Medicine-Internal Medicine/Oncology ( Site 0062)

St Louis, Missouri, United States

University Of Nebraska Medical Center-Oncology/Hematology ( Site 0095)

Omaha, Nebraska, United States

Comprehensive Cancer Centers of Nevada ( Site 0010)

Las Vegas, Nevada, United States

Atlantic Health System Morristown Medical Center ( Site 0115)

Morristown, New Jersey, United States

Rutgers Cancer Institute of New Jersey ( Site 0033)

New Brunswick, New Jersey, United States

James J. Peters VA Medical Center ( Site 0088)

The Bronx, New York, United States

University Hospitals Cleveland Medical Center ( Site 0043)

Cleveland, Ohio, United States

Oregon Health and Science University ( Site 0028)

Portland, Oregon, United States

VA Portland Health Care System ( Site 0058)

Portland, Oregon, United States

AHN Allegheny General Hospital ( Site 0001)

Pittsburgh, Pennsylvania, United States

Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083)

Charleston, South Carolina, United States

Avera Cancer Institute - Pierre ( Site 0118)

Pierre, South Dakota, United States

Avera Cancer Institute- Research ( Site 0094)

Sioux Falls, South Dakota, United States

Avera Cancer Institute - Yankton ( Site 0117)

Yankton, South Dakota, United States

SCRI Oncology Partners ( Site 7000)

Nashville, Tennessee, United States

Texas Oncology - Central/South Texas ( Site 8003)

Austin, Texas, United States

Texas Oncology - DFW ( Site 8001)

Dallas, Texas, United States

Texas Oncology - Gulf Coast ( Site 8002)

The Woodlands, Texas, United States

University of Virginia Health System ( Site 0054)

Charlottesville, Virginia, United States

VCU Health Adult Outpatient Pavillion ( Site 0061)

Richmond, Virginia, United States

Blue Ridge Cancer Care ( Site 0004)

Roanoke, Virginia, United States

Fred Hutchinson Cancer Center ( Site 0013)

Seattle, Washington, United States

MEDICAL COLLEGE OF WISCONSIN ( Site 0020)

Milwaukee, Wisconsin, United States

Hospital Británico de Buenos Aires-Oncology ( Site 0202)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201)

Mar del Plata, Buenos Aires, Argentina

Instituto Alexander Fleming-Alexander Fleming ( Site 0206)

Buenos Aires, Buenos Aires F.D., Argentina

Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)

Buenos Aires, Buenos Aires F.D., Argentina

Sanatorio Parque ( Site 0208)

Rosario, Santa Fe Province, Argentina

Hospital Aleman-Oncology ( Site 0207)

Buenos Aires, Argentina

Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0204)

Mendoza, Argentina

Dubbo Hospital ( Site 0235)

Dubbo, New South Wales, Australia

Macquarie University-MQ Health Clinical Trials Unit ( Site 0234)

Macquarie University, New South Wales, Australia

Westmead Hospital ( Site 0232)

Westmead, New South Wales, Australia

Princess Alexandra Hospital-Cancer Care Serices ( Site 0237)

Brisbane, Queensland, Australia

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0230)

Melbourne, Victoria, Australia

Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 0280)

Graz, Styria, Austria

Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0276)

Linz, Upper Austria, Austria

Klinikum Wels-Grieskirchen GmbH ( Site 0279)

Wels, Upper Austria, Austria

Hospital Santa Rita de Cassia-Centro de Pesquisa Clínica ( Site 0320)

Vitória, Espírito Santo, Brazil

Obras Sociais Irma Dulce ( Site 0302)

Salvador, Estado de Bahia, Brazil

Hospital Felicio Rocho ( Site 0317)

Belo Horizonte, Minas Gerais, Brazil

Hospital Mario Penna ( Site 0309)

Belo Horizonte, Minas Gerais, Brazil

Hospital Universitário Evangélico Mackenzie-Centro de Oncologia Mackenzie ( Site 0314)

Curitiba, Paraná, Brazil

Clínica de Neoplasias Litoral ( Site 0305)

Itajaí, Santa Catarina, Brazil

Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0308)

Bragança Paulista, São Paulo, Brazil

A. C. Camargo Cancer Center ( Site 0310)

São Paulo, São Paulo, Brazil

Cross Cancer Institute ( Site 0332)

Edmonton, Alberta, Canada

The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0336)

Ottawa, Ontario, Canada

Sunnybrook Research Institute ( Site 0331)

Toronto, Ontario, Canada

Princess Margaret Cancer Centre ( Site 0330)

Toronto, Ontario, Canada

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0328)

Greenfield Park, Quebec, Canada

Centre Hospitalier de l'Université de Montréal ( Site 0326)

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0327)

Québec, Quebec, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0329)

Sherbrooke, Quebec, Canada

IC La Serena Research ( Site 0356)

La Serena, Coquimbo Region, Chile

Clinical Research Chile SpA ( Site 0358)

Valdivia, Los Ríos Region, Chile

Clinica Universidad Catolica del Maule-Oncology ( Site 0355)

Talca, Maule Region, Chile

FALP ( Site 0353)

Santiago, Region M. de Santiago, Chile

Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0354)

Santiago, Region M. de Santiago, Chile

Bradfordhill-Clinical Area ( Site 0351)

Santiago, Region M. de Santiago, Chile

Bradford Hill Norte ( Site 0357)

Antofagasta, Chile

Second Affiliated hospital of Anhui Medical University-Urology ( Site 0408)

Hefei, Anhui, China

Peking University First Hospital-Urology ( Site 0390)

Beijing, Beijing Municipality, China

Beijing Friendship Hospital Affiliate of Capital University ( Site 0396)

Beijing, Beijing Municipality, China

Beijing Cancer hospital-Urinary Surgery ( Site 0395)

Beijing, Beijing Municipality, China

The First Affiliated Hospital of Chongqing Medical University ( Site 0427)

Chongqing, Chongqing Municipality, China

Chongqing University Cancer Hospital ( Site 0416)

Chongqing, Chongqing Municipality, China

Southwest Hospital of Third Military Medical University ( Site 0420)

Chongqing, Chongqing Municipality, China

Chongqing Three Gorges Central Hospital's ( Site 0426)

Chongqing, Chongqing Municipality, China

The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0414)

Fuzhou, Fujian, China

The First Affiliated hospital of Xiamen University-Urology ( Site 0415)

Xiamen, Fujian, China

The First Affiliated Hospital of Guangzhou Medical University ( Site 0412)

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center-Internal medicine ( Site 0413)

Guangzhou, Guangdong, China

Tongji Hospital Tongji Medical,Science & Technology ( Site 0407)

Wuhan, Hubei, China

Hubei Cancer Hospital-Urinary surgery ( Site 0406)

Wuhan, Hubei, China

Hunan Cancer Hospital ( Site 0405)

Changsha, Hunan, China

First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 0436)

Huaian, Jiangsu, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 0377)

Nanjing, Jiangsu, China

Affiliated hospital of Jiangnan university ( Site 0434)

Wuxi, Jiangsu, China

Jiangxi Cancer Hospital ( Site 0386)

Nanchang, Jiangxi, China

The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 0394)

Xi'an, Shaanxi, China

The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0393)

Xi'an, Shaanxi, China

Yantai Yuhuangding Hospital ( Site 0397)

Yantai, Shandong, China

Zhongshan Hospital of Fudan University (0430)

Shanghai, Shangai, China

Fudan University Shanghai Cancer Center-Urology department ( Site 0376)

Shanghai, Shanghai Municipality, China

Huadong Hospital Affiliated to Fudan University-Urology ( Site 0388)

Shanghai, Shanghai Municipality, China

The Third People's Hospital of Chengdu (CDTPH) ( Site 0428)

Chengdu, Sichuan, China

West China Hospital, Sichuan University-Urology Surgery ( Site 0417)

Chengdu, Sichuan, China

Nanchong Central Hospital-urology ( Site 0422)

Nanchong, Sichuan, China

Suining Central Hospital ( Site 0437)

Suining, Sichuan, China

Tianjin Medical University Cancer Institute & Hospital ( Site 0392)

Tianjin, Tianjin Municipality, China

The Second Hospital of Tianjin Medical University ( Site 0391)

Tianjin, Tianjin Municipality, China

Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 0419)

Ürümqi, Xinjiang, China

The Second Affiliated Hospital Of Kunming Medical University ( Site 0429)

Kunming, Yunnan, China

Yunnan Province Cancer Hospital ( Site 0418)

Kunming, Yunnan, China

Zhejiang Provincial People's Hospital-Urology ( Site 0378)

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital ( Site 0435)

Hangzhou, Zhejiang, China

The First Hospital of Jiaxing-urology ( Site 0380)

Jiaxing, Zhejiang, China

The First Affiliated Hospital of Ningbo University ( Site 0383)

Ningbo, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0379)

Wenzhou, Zhejiang, China

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0501)

Bogotá, Bogota D.C., Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0502)

Valledupar, Cesar Department, Colombia

IMAT S.A.S ( Site 0504)

Montería, Departamento de Córdoba, Colombia

Fundación Cardiovascular de Colombia ( Site 0503)

Piedecuesta, Santander Department, Colombia

Fundación Valle del Lili ( Site 0505)

Cali, Valle del Cauca Department, Colombia

Clínica Imbanaco S.A.S ( Site 0509)

Cali, Valle del Cauca Department, Colombia

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0553)

Brno, Brno-mesto, Czechia

Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0554)

Ostrava, Moravskoslezský kraj, Czechia

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0555)

Olomouc, Olomoucký kraj, Czechia

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0551)

Prague, Praha 5, Czechia

Rigshospitalet ( Site 0576)

Copenhagen, Capital Region, Denmark

Odense Universitetshospital-Department of oncology ( Site 0579)

Odense, Region Syddanmark, Denmark

Vejle Sygehus ( Site 0578)

Vejle, Region Syddanmark, Denmark

Kuopion Yliopistollinen Sairaala ( Site 0603)

Kuopio, Northern Savonia, Finland

Tampereen yliopistollinen sairaala ( Site 0604)

Tampere, Pirkanmaa, Finland

Turku University Hospital-Department of Oncology ( Site 0601)

Turku, Southwest Finland, Finland

Centre Oscar Lambret (Site 0634)

Lille, Ain, France

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0627)

Strasbourg, Alsace, France

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 0630)

Nîmes, Gard, France

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0632)

Rennes, Ille-et-Vilaine, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0629)

Clermont-Ferrand, Puy-de-Dome, France

Centre Hospitalier de la Côte Basque ( Site 0633)

Bayonne, Pyrenees-Atlantiques, France

Gustave Roussy ( Site 0626)

Villejuif, Val-de-Marne, France

Hôpital Européen Georges Pompidou ( Site 0628)

Paris, France

klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0696)

Munich, Bavaria, Germany

HELIOS Kliniken Schwerin ( Site 0694)

Schwerin, Mecklenburg-Vorpommern, Germany

Universitätsklinikum Bonn-Klinik und Poliklinik für Urologie und Kinderurologie ( Site 0680)

Bonn, North Rhine-Westphalia, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus-Klinik für Urologie ( Site 0678)

Münster, North Rhine-Westphalia, Germany

Universitätsklinikum Schleswig-Holstein-Klinik für Urologie ( Site 0691)

Lübeck, Schleswig-Holstein, Germany

Universitätsklinikum Jena-Klinik und Poliklinik für Urologie ( Site 0682)

Jena, Thuringia, Germany

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0679)

Berlin, Germany

Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0705)

Hamburg, Germany

Queen Mary Hospital ( Site 0727)

Hong Kong, Hong Kong

Prince of Wales Hospital ( Site 0730)

Shatin, Hong Kong

Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 0752)

Kecskemét, Bács-Kiskun county, Hungary

Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0761)

Salgótarján, Nógrád megye, Hungary

Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0756)

Budapest, Pest County, Hungary

Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0758)

Debrecen, Hungary

St. Vincent's University Hospital ( Site 0802)

Dublin, Dublin, Ireland

Tallaght University Hospital ( Site 0801)

Dublin, Ireland

Emek Medical Center ( Site 0830)

Afula, Israel

Rambam Health Care Campus-Oncology Division ( Site 0826)

Haifa, Israel

Hadassah Medical Center ( Site 0833)

Jerusalem, Israel

Meir Medical Center. ( Site 0832)

Kfar Saba, Israel

Rabin Medical Center ( Site 0828)

Petah Tikva, Israel

Sheba Medical Center ( Site 0827)

Ramat Gan, Israel

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 0879)

Meldola, Emilia-Romagna, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0877)

Milan, Lombardy, Italy

Ospedale San Raffaele-Oncologia Medica ( Site 0876)

Milan, Italy

Toho University Sakura Medical Center ( Site 0906)

Sakura, Chiba, Japan

Ehime University Hospital ( Site 0918)

Tōon, Ehime, Japan

Hospital of the University of Occupational and Environmental Health, Japan ( Site 0921)

Kitakyushu, Fukuoka, Japan

Kurume University Hospital ( Site 0920)

Kurume, Fukuoka, Japan

Asahikawa Medical University Hospital ( Site 0901)

Asahikawa, Hokkaido, Japan

Sapporo Medical University Hospital ( Site 0902)

Sapporo, Hokkaido, Japan

Hokkaido University Hospital ( Site 0931)

Sapporo, Hokkaido, Japan

Kobe University Hospital ( Site 0914)

Kobe, Hyōgo, Japan

Kanazawa Medical University Hospital ( Site 0909)

Mukai-awagasaki, Ishikawa-ken, Japan

Kagawa University Hospital ( Site 0917)

Kita, Kagawa-ken, Japan

Yokohama City University Medical Center ( Site 0908)

Yokohama, Kanagawa, Japan

National Hospital Organization Nagasaki Medical Center ( Site 0923)

Ōmura, Nagasaki, Japan

Nara Medical University Hospital ( Site 0915)

Kashihara, Nara, Japan

Nanbu Tokushukai Hospital ( Site 0930)

Shimajiri, Okinawa, Japan

Kansai Medical University Hospital ( Site 0912)

Hirakata, Osaka, Japan

Bell Land General Hospital ( Site 0913)

Sakai, Osaka, Japan

The University of Osaka Hospital ( Site 0911)

Suita, Osaka, Japan

Saga-Ken Medical Centre Koseikan ( Site 0922)

Saga, Saga-ken, Japan

The Jikei University Hospital ( Site 0907)

Minato, Tokyo, Japan

Akita University Hospital ( Site 0904)

Akita, Japan

Kyushu University Hospital ( Site 0919)

Fukuoka, Japan

Fukushima Medical University Hospital ( Site 0933)

Fukushima, Japan

Gifu University Hospital ( Site 0910)

Gifu, Japan

Hiroshima University Hospital ( Site 0916)

Hiroshima, Japan

Kagoshima University Hospital ( Site 0929)

Kagoshima, Japan

National Hospital Organization Kumamoto Medical Center ( Site 0924)

Kumamoto, Japan

Miyazaki Prefectural Miyazaki Hospital ( Site 0927)

Miyazaki, Japan

University of Miyazaki Hospital ( Site 0926)

Miyazaki, Japan

Nagano Municipal Hospital ( Site 0932)

Nagano, Japan

National Hospital Organization Oita Medical Center ( Site 0925)

Ōita, Japan

Hospital Sultan Ismail ( Site 1081)

Johor Bahru, Johor, Malaysia

University Malaya Medical Centre ( Site 1077)

Lembah Pantai, Kuala Lumpur, Malaysia

National Cancer Institute ( Site 1079)

Putrajaya, Putrajaya, Malaysia

Sarawak General Hospital-Radiotherapy Unit ( Site 1076)

Kuching, Sarawak, Malaysia

Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1078)

Kuala Lumpur, Malaysia

CIO - Centro de Inmuno-Oncología de Occidente ( Site 1103)

Guadalajara, Jalisco, Mexico

Quemex Medical and Research ( Site 1112)

Mexico City, Mexico City, Mexico

Filios Alta Medicina ( Site 1106)

Monterrey, Nuevo León, Mexico

Medical Care and Research SA de CV ( Site 1108)

Mérida, Yucatán, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 1109)

Oaxaca City, Mexico

Radboudumc-Medical Oncology ( Site 1152)

Nijmegen, Gelderland, Netherlands

Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1163)

Sittard-Geleen, Limburg, Netherlands

VieCuri Medisch Centrum ( Site 1173)

Venlo, Limburg, Netherlands

ETZ Elisabeth-Internal Medicine ( Site 1160)

Tilburg, North Brabant, Netherlands

Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 1153)

Amsterdam, North Holland, Netherlands

Amsterdam UMC, locatie VUmc ( Site 1156)

Amsterdam, North Holland, Netherlands

Spaarne Gasthuis - Hoofddorp-Oncology ( Site 1170)

Hoofddorp, North Holland, Netherlands

Medische Centrum Leeuwarden ( Site 1172)

Leeuwarden, Provincie Friesland, Netherlands

Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1151)

Schiedam, South Holland, Netherlands

Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1164)

The Hague, South Holland, Netherlands

Meander Medisch Centrum ( Site 1157)

Amersfoort, Utrecht, Netherlands

Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 1201)

Tauranga, Bay of Plenty, New Zealand

Dunedin Hospital-Southern Blood and Cancers Service ( Site 1203)

Dunedin, Otago, New Zealand

Akershus Universitetssykehus-Onkologisk avdeling ( Site 1227)

Lørenskog, Akershus, Norway

St. Olavs Hospital-Kreftklinikken ( Site 1231)

Trondheim, Sor-Trondelag, Norway

Sykehuset Østfold Kalnes ( Site 1228)

Sarpsborg, Østfold fylke, Norway

Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 1258)

Concepción, Departamento de Junín, Peru

Clínica Sánchez Ferrer ( Site 1261)

Trujillo, La Libertad, Peru

Aliada-Oncologìa ( Site 1257)

Lima, Peru

IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1254)

Lima, Peru

Oncosalud-Clinical Research ( Site 1260)

Lima, Peru

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1256)

Lima, Peru

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1302)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1316)

Grudziądz, Kuyavian-Pomeranian Voivodeship, Poland

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 1304)

Torun, Kuyavian-Pomeranian Voivodeship, Poland

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1310)

Siedlce, Masovian Voivodeship, Poland

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1303)

Koszalin, West Pomeranian Voivodeship, Poland

Zachodniopomorskie Centrum Onkologii ( Site 1311)

Szczecin, West Pomeranian Voivodeship, Poland

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 1318)

Kielce, Świętokrzyskie Voivodeship, Poland

Puerto Rico Medical Research Center LLC ( Site 1354)

Hato Rey, Puerto Rico

Ad-Vance Medical Research-Research ( Site 1353)

Ponce, Puerto Rico

Pan American Center for Oncology Trials - Ciudadela ( Site 1351)

San Juan, Puerto Rico

National University Hospital ( Site 1376)

Singapore, Central Singapore, Singapore

National Cancer Centre Singapore ( Site 1377)

Singapore, Central Singapore, Singapore

Tan Tock Seng Hospital-Medical Oncology ( Site 1378)

Singapore, Central Singapore, Singapore

Asan Medical Center-Oncology ( Site 1402)

Songpagu, Seoul, South Korea

Seoul National University Hospital-Oncology ( Site 1401)

Seoul, South Korea

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1404)

Seoul, South Korea

Samsung Medical Center ( Site 1405)

Seoul, South Korea

Hospital Jerez de la Frontera ( Site 1427)

Jerez de la Frontera, Cadiz, Spain

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1431)

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1433)

Madrid, Madrid, Comunidad de, Spain

Complexo Hospitalario Universitario de Ourense ( Site 1426)

Ourense, Orense, Spain

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1430)

Valencia, Valenciana, Comunitat, Spain

Hospital Lucus Augusti-Oncology ( Site 1432)

Lugo, Spain

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1428)

Seville, Spain

Karolinska Universitetssjukhuset Solna ( Site 1478)

Stockholm, Stockholm County, Sweden

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1477)

Uppsala, Uppsala County, Sweden

Sahlgrenska Universitetssjukhuset ( Site 1479)

Gothenburg, Västra Götaland County, Sweden

China Medical University Hospital-Department of Urology ( Site 1503)

Taichung, Taiwan

National Cheng Kung University Hospital-Urology ( Site 1502)

Tainan, Taiwan

National Taiwan University Hospital-Urology ( Site 1506)

Taipei, Taiwan

Taipei Veterans General Hospital ( Site 1505)

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1504)

Taoyuan District, Taiwan

Chulalongkorn University ( Site 1530)

Bangkok, Bangkok, Thailand

Faculty of Medicine Siriraj Hospital ( Site 1531)

Bangkok, Bangkok, Thailand

Faculty of Medicine - Khon Kaen University ( Site 1526)

Muang, Changwat Khon Kaen, Thailand

Songklanagarind hospital ( Site 1527)

Hat Yai, Changwat Songkhla, Thailand

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1554)

Adana, Turkey (Türkiye)

Gulhane Egitim Arastirma Hastanesi ( Site 1558)

Ankara, Turkey (Türkiye)

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1551)

Ankara, Turkey (Türkiye)

Memorial Ankara Hastanesi-Medical Oncology ( Site 1557)

Ankara, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1552)

Ankara, Turkey (Türkiye)

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1555)

Istanbul, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1553)

Istanbul, Turkey (Türkiye)

Samsun Medical Park Hastanesi-medical oncology (1560)

Samsun, Turkey (Türkiye)

Addenbrooke's Hospital ( Site 1605)

Cambridge, Cambridgeshire, United Kingdom

The Royal Cornwall Hospital ( Site 1610)

Truro, England, United Kingdom

The Beatson West of Scotland Cancer Centre ( Site 1603)

Glasgow, Glasgow City, United Kingdom

Charing Cross Hospital-Oncology Research ( Site 1606)

London, Hammersmith and Fulham, United Kingdom

University College London Hospital ( Site 1612)

London, London, City of, United Kingdom

The Christie NHS Foundation Trust ( Site 1608)

Manchester, United Kingdom