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Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation
Sponsor: University of Oklahoma
Summary
This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay (LOS) in the general hospital floor vs pediatric intensive care unit (PICU), and decrease the need for respiratory support.
Key Details
Gender
All
Age Range
5 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-11-30
Completion Date
2025-05-31
Last Updated
2024-12-06
Healthy Volunteers
No
Conditions
Interventions
Magnesium Sulfate within the first hour
The experimental group will receive 40-50 mg/kg of IV magnesium sulfate will be given to the experimental group alongside the first line asthma therapies (ie inhaled beta agonists, IV steroids). This will be given with a 20 mL/kg normal saline bolus (max 1000 mL) to avoid possible hypotension. 15-19 kg: 750 mg 20-29 kg: 1000 mg 30-39 kg: 1500 mg \>40 kg: 2000 mg
No Magnesium sulfate within the first hour
The control group will not receive IV magnesium sulfate within the first hour of treatment.
Locations (1)
Oklahoma Children's Hospital
Oklahoma City, Oklahoma, United States