Inclusion Criteria:
1. Healthy adults over 50 years old and under 65 years old
2. Those who voluntarily decided to participate and gave written consent after hearing and understanding the detailed explanation of this clinical trial
3. Women with childbearing potential and those who agree to use the contraceptive method\* permitted up to 3 months after the final vaccination for clinical trials (\* Combination use such as hormonal contraception, intrathyroidal device (IUD (Intrauterine device) or IUS (Intrauterine system), vasectomy, tubal stomy, double block method (cervical cap, use with contraceptive diaphragm)
4. Women of childbearing potential with negative result at pregnancy test before vaccination for clinical trials.
Exclusion Criteria:
1. Those with a past history of shingles before screening
2. Persons with hypersensitivity to clinical investigational products or the ingredients of clinical investigational products
3. Those with thrombocytopenia or other coagulation disorders who should not receive intramuscular injections, or those receiving anticoagulant therapy\*
\*Anticoagulant therapy: Continuous use of anticoagulants such as coumarin/warfarin or new oral anticoagulants/antiplatelet agents
4. Those with a history of immune dysfunction, including immunodeficiency disease
5. Those suffering from chronic underlying diseases that, in the opinion of the investigator, may interfere with the progress and completion of this clinical trial
6. Those with a history of excessive alcohol consumption or drug addiction
7. Persons with a history of serious adverse events, allergies or hypersensitivity reactions related to vaccination (e.g. anaphylaxis, Guillain-Barré Syndrome)
8. Those with a history of malignant tumor
9. Those who developed a fever (tympanic membrane temperature of 38.0°C or higher) within 3 days prior to the first vaccination of clinical investigational product, suffered from a febrile illness on the day of vaccination, or suffered from a disease with moderate or more acute symptoms (mild illness without fever) (e.g. If you have mild diarrhoea, mild upper respiratory infection), you can participate in the clinical trial at the discretion of the investigator.)
10. Those who have received chickenpox or shingles vaccine before screening
11. Those who have participated in past chickenpox or shingles vaccine clinical trials
12. Those who have been vaccinated with another vaccine within 4 weeks prior to the first injection of the investigational product, or who plan to be vaccinated with another vaccine by 48 weeks after the second injection of the investigational product (however, seasonal or pandemic flu) (inactivated and subunit influenza vaccine and COVID-19 vaccine for prevention of flu) are contraindicated only within 2 weeks before and after vaccination of each clinical investigational product)
13. Those who have received blood products or immunoglobulin within 3 months prior to receiving the first clinical investigational product, or those who plan to administer it during the clinical trial period
14. Those who have received immunosuppressants, immunomodulating drugs, other cytotoxic anticancer drugs that may affect immunity, or have experienced radiation therapy within 6 months prior to receiving the first clinical investigational product.
15. Those who have experienced systemic steroid administration within 3 months prior to receiving the first clinical investigation drug (those who are taking a dose of 20 mg/day or more based on prednisone continuously for more than 2 weeks) However, topical, inhalation ( Inhaled, intranasal, intra-articular, and intra-bursal administration is permitted regardless of dosage.
16. Organ transplant or hematopoietic stem cell transplant patients
17. Those with positive virus test results (HCV Ab, HBsAg, HIV Ab) performed at screening
18. Persons with clinically significant abnormalities in tests performed during screening (clinical laboratory tests, electrocardiogram, vital signs, etc.)
19. Those taking antiviral drugs (Acyclovir, Valacyclovir, Famciclovir, Ganciclovir, etc.) known to be effective against varicella-zoster virus at the time of screening (topical use of antiviral drugs is permitted)
20. Those with a history of active tuberculosis
21. A person who has received another clinical investigational product or applied a clinical trial medical device within 6 months before participating in a clinical trial
22. Pregnant or lactating women
23. If the investigator determines that the subject is unsuitable for this clinical trial for other reasons
