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The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Sponsor: Beijing Tiantan Hospital
Summary
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Official title: The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-08-31
Completion Date
2025-12-31
Last Updated
2025-02-14
Healthy Volunteers
No
Interventions
Dexmedetomidine
Participants will be sedated and maintained by dexmedetomidine during the surgery.
Propofol
Participants will be sedated and maintained by propofol during the surgery.
Remimazolam Injection
Participants will be sedated and maintained by remimazolam during the surgery.
Locations (1)
Beijing Tian Tan Hospital, Capital Medical University
Beijing, Beijing Municipality, China