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Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models
Sponsor: Beth Israel Deaconess Medical Center
Summary
The goal of this prospective observational cohort study is to validate previously developed Hepatocellular Carcinoma (HCC) risk prediction algorithms, the Liver Risk Computation (LIRIC) models, which are based on electronic health records. The main questions it aims to answer are: * Will our retrospectively developed general population LIRIC models, developed on routine EHR data, perform similarly when prospectively validated, and reliably and accurately predict HCC in real-time? * What is the average time from model deployment and risk prediction, to the date of HCC development and what is the stage of HCC at diagnosis? The risk model will be deployed on data from individuals eligible for the study. Each individual will be assigned a risk score and tracked over time to assess the model's discriminatory performance and calibration.
Official title: Prospective Validation of Liver Cancer Risk Computation (LIRIC) Models on Multicenter EHR Data
Key Details
Gender
All
Age Range
40 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
6000000
Start Date
2023-04-01
Completion Date
2027-03-31
Last Updated
2025-05-25
Healthy Volunteers
Yes
Conditions
Interventions
Liver Risk Computation Model (LIRIC)
A neural network model (LIRIC-NN) and a logistic regression model (LIRIC-LR) that use routinely collected EHR data to stratify individuals into HCC risk groups for the general population
Liver Risk Computation Model (LIRIC)_cirrhosis
A neural network model (LIRIC-NN) and a logistic regression model (LIRIC-LR) that use routinely collected EHR data to stratify individuals into HCC risk groups for the population with liver cirrhosis
Liver Risk Computation Model (LIRIC)_no_cirrhosis
neural network model (LIRIC-NN) and a logistic regression model (LIRIC-LR) that use routinely collected EHR data to stratify individuals into HCC risk groups for the population without liver cirrhosis
Locations (1)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States