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RECRUITING
NCT06141265
PHASE2

Niraparib Maintenance in HRD-Positive Advanced Ovarian Cancer Following Front-Line Chemotherapy + Bevacizumab

Sponsor: Peking University Cancer Hospital & Institute

View on ClinicalTrials.gov

Summary

This study is a multicenter, open-label, single-arm phase II clinical trial investigating the efficacy and safety of niraparib monotherapy maintenance in HRD-positive newly diagnosed advanced epithelial ovarian cancer (EOC), including primary peritoneal and/or fallopian tube tumors, following response to front-line chemotherapy in combination with bevacizumab. A total of 116 patients will be enrolled.

Official title: Chemotherapy Combined With Bevacizumab Followed by Niraparib Monotherapy in Newly Diagnostic Advanced Ovarian Cancer With HRD Positive : A Perspective, Multicenter, Single-arm Phase II Trial

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

116

Start Date

2023-11-01

Completion Date

2027-09

Last Updated

2023-11-21

Healthy Volunteers

No

Interventions

DRUG

Niraparib

The starting dose is 300mg or 200mg QD based on the subject's baseline body weight or baseline platelet count

Locations (1)

Peking University Cancer Hospital

Beijing, Beijing Municipality, China