Clinical Research Directory

Key Inclusion Criteria * Hemophilia patients with liver cirrhosis caused by HIV/HCV co-infection that fall under the following 1) and 2): 1. Serum HIV-RNA positive or HIV antibody positive patients (maintaining HIV-RNA \< 200 copies/mL and CD4 positive T lymphocyte count \>= 200 cells/µL at screening). 2. Regarding HCV, patients who had passed \>= 12 months after achieving SVR at registration. * Patients with Child-Pugh classification A or B (Child-Pugh score 5-9). * Patients who meet at least one of 1) to 2) for diagnosis of liver cirrhosis: 1. Liver stiffness measurement by FibroScan is \>= 12.5 kPa (Fibrosis stage F4) at screening. 2. Abdominal CT scan shows changes in liver shape and/or portal hypertension. * Patients with Performance Status 0-2. Key Exclusion Criteria * Patients with liver cirrhosis of which cause is not HCV or unknown. * Patients with esophageal gastric varices judged to require treatment by endoscopic examinations at screening. * Patients with complication or history of malignant tumor (within 3 years before registration). * Patients who have undergone liver transplantation or other organ transplantation (including bone marrow transplantation). * Patients with active AIDS-indicator disease that require treatment.