Clinical Research Directory
Browse clinical research sites, groups, and studies.
Prophylactic Tributyrin Supplementation in Acute Pancreatitis
Sponsor: St. Antonius Hospital
Summary
The goal of this clinical trial is to investigate the possible effects of tributyrin supplementation in patients with a first episode of acute pancreatitis. The main question it aims to answer is: • The effect of oral tributyrin supplementation on the plasma endotoxin level Participants will be randomized between two groups: intervention and control group. They will receive: \- three times daily 4grams of micro-encapsulated granules of tributyrin, and the control group three times daily 4 grams of micro-encapsulated sunflower oil (i.e. placebo), for a total of 14 days In total 92 adult patients with a first episode of acute pancreatitis will be included.
Official title: Prophylactic Tributyrin Supplementation in Acute Pancreatitis; a Phase IIa (Proof of Concept) Double-blind Randomized Placebo-controlled Food Supplement Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
92
Start Date
2024-02-12
Completion Date
2027-01
Last Updated
2024-06-20
Healthy Volunteers
No
Conditions
Interventions
Micro-encapsulated granules of tributyrin (intervention)
Three times daily 4 grams of micro-encapsulated granules of tributyrin, for a maximum of 14 days
Micro-encapsulated granules of sunflower oil (placebo)
Three times daily 4 grams of micro-encapsulated granules of sunflower oil, for a maximum of 14 days
Locations (2)
Reinier de Graaf Gasthuis
Delft, South Holland, Netherlands
St. Antonius Hospital
Nieuwegein, Utrecht, Netherlands