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French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
Sponsor: University Hospital, Limoges
Summary
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS. Participants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2024-09-17
Completion Date
2029-09-30
Last Updated
2024-11-25
Healthy Volunteers
No
Conditions
Interventions
Blood sample
Blood sample will be taken to identify Genomic, metabolomic, metabolic, neurofilaments, and inflammation markers associated to weight loss
Locations (7)
CHU de Lille
Lille, France
Limoges University Hospital
Limoges, France
Hôpital de la Timone
Marseille, France
Hôpital Gui Chauliac
Montpellier, France
CHU de Nice
Nice, France
Hôpital de la Pitié Salpêtrière
Paris, France
CHU de Tours
Tours, France