Clinical Research Directory

Inclusion Criteria: * Aged 55 or more * BMI between 25-30, * Waist-to-hip ratio of at least 0.90 (males) or 0.85 (females) * Omega-3 index \<6 Exclusion Criteria: * Dementia * Current clinically significant depression, i.e. major depression or GDS 15 score \>7 * Ischemic or haemorrhagic Stroke * Acute myocardial infarction * Any form of clinically significant atherosclerotic cardiovascular disease * Unstable angina pectoris * Hearth failure in need of treatment * Diabetes mellitus type 1 or 2 * Clinically relevant kidney diseases that require dialysis, including clinically significant chronic kidney disease * Liver cirrhosis or active hepatitis B or C * Cancer of any kind; however, benign tumours are no exclusion criterium * Clinically relevant inflammatory or autoimmune disorders with history of hospitalisation * Any form of systemic lupus erythematosus (SLE), rheumatoid arthritis, Colitis ulcerosa, Crohn's disease, Morbus Parkinson, Multiple Sclerosis * hsCRP \> 3.0 mg/L to exclude high risk individuals according to international criteria * LDL-C \> 160mg/dL to exclude individuals with high risk for arterioscleratic coronary disease26 * HBa1C \< 6.5% to exclude diabetes * Fasting Triglycerides \>200 mg/dL * Omega 3 index \> 6 % (as they may not show any benefit from supplementation) * Use of fish oil / omega 3 supplements over the last 6 months * Fish allergy * Antibiotic use in the last 24 weeks