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A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Sponsor: Mayo Clinic
Summary
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Official title: A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-04-01
Completion Date
2028-06-01
Last Updated
2025-08-03
Healthy Volunteers
No
Conditions
Interventions
Losartan
50mg administered orally once daily for 52 weeks.
Amlodipine
5mg Amlodipine administered orally once daily for 52 weeks.
Placebo
Oral capsules that contain no active drug ingredients administered orally once daily for 52 weeks.
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States