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RECRUITING

NCT06152575

PHASE3

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

Sponsor: Pfizer

View on ClinicalTrials.gov

Summary

The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.

Official title: A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

492

Start Date

2024-02-08

Completion Date

2027-12-30

Last Updated

2026-03-20

Healthy Volunteers

Conditions

Multiple Myeloma

Interventions

DRUG

Elranatamab

Elranatamab will be administered subcutaneously

DRUG

Elotuzumab

Elotuzumab will be administered intravenously

DRUG

Pomalidomide

Pomalidomide will be administered orally

DRUG

Dexamethasone

Dexamethasone will be administered orally

DRUG

Bortezomib

Bortezomib will be administered subcutaneously or intravenously

DRUG

Carfilzomib

Carfilzomib will be administered intravenously

Locations (277)

Infirmary Cancer Care

Mobile, Alabama, United States

Western Regional Medical Center, Inc. dba. City of Hope Phoenix

Goodyear, Arizona, United States

Beverly Hills Cancer Center

Beverly Hills, California, United States

Community Cancer Institute

Clovis, California, United States

Clinical Research Advisors (Encino Satellite Location)

Encino, California, United States

Hoag Health Center Irvine

Irvine, California, United States

Hoag Hospital Irvine

Irvine, California, United States

Clinical Research Advisors (Korea Town Satellite Location)

Los Angeles, California, United States

Clinical Research Advisors (West Hollywood Satellite Location)

Los Angeles, California, United States

Valkyrie Clinical Trials

Los Angeles, California, United States

Hoag Memorial Hospital Presbyterian

Newport Beach, California, United States

Mission Community Hospital (Satellite Site)

Panorama City, California, United States

University of California Davis (UC Davis) Comprehensive Cancer Center

Sacramento, California, United States

University of California

Sacramento, California, United States

UCHealth Poudre Valley Hospital

Fort Collins, Colorado, United States

UCHealth Harmony

Fort Collins, Colorado, United States

UCHealth Greeley Hospital

Greeley, Colorado, United States

UCHealth Longs Peak Hospital

Longmont, Colorado, United States

UCHealth Longs Peak Medical Center

Longmont, Colorado, United States

UCHealth - Medical Center of the Rockies

Loveland, Colorado, United States

Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center

Coral Gables, Florida, United States

University of Miami Hospital and Clinics - Deerfield Beach

Deerfield Beach, Florida, United States

Sylvester Comprehensive Cancer Center- Doral

Doral, Florida, United States

Sylvester Comprehensive Cancer Center - Hollywood

Hollywood, Florida, United States

Sylvester Comprehensive Cancer Center

Miami, Florida, United States

University of Miami Hospital and Clinics - Griffin Cancer Research Building

Miami, Florida, United States

University of Miami Hospital and Clinics

Miami, Florida, United States

Baptist Hospital of Miami

Miami, Florida, United States

Sylvester Comprehensive Cancer Center- Kendall

Miami, Florida, United States

BRCR Global

Plantation, Florida, United States

BRCR Global - Tamarac

Tamarac, Florida, United States

Endeavor Health - Swedish Hospital

Chicago, Illinois, United States

Endeavor Health - Evanston Hospital

Evanston, Illinois, United States

Endeavor Health - Glenbrook Hospital Ambulatory Care Center

Glenview, Illinois, United States

Endeavor Health - Highland Park Hospital Health Center 1

Highland Park, Illinois, United States

Simmons Cancer Institute at SIU

Springfield, Illinois, United States

Springfield Clinic Main Campus

Springfield, Illinois, United States

HSHS St. John's Hospital

Springfield, Illinois, United States

Springfield Memorial Hospital

Springfield, Illinois, United States

Midwestern Regional Medical Center, Inc. dba City of Hope Chicago

Zion, Illinois, United States

Community Health Network, Inc.

Indianapolis, Indiana, United States

Community Health Network, Inc.

Indianapolis, Indiana, United States

Community Health Network, Inc.

Indianapolis, Indiana, United States

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Kansas City, Kansas, United States

Ascentist Doctors' Hospital

Leawood, Kansas, United States

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Merriam, Kansas, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

BIDMC Research Pharmacy

Boston, Massachusetts, United States

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Belton, Missouri, United States

MIVA Medical

Independence, Missouri, United States

Kansas City VA Medical Center

Kansas City, Missouri, United States

American Oncology Partners, P.A. Dba MidAmerica Cancer Care

Kansas City, Missouri, United States

Bryan Medical Center

Lincoln, Nebraska, United States

NHO Revive Research Institute, LLC

Lincoln, Nebraska, United States

Atlantic Health System Morristown Medical Center

Morristown, New Jersey, United States

WMCHealth Advanced Physician Services

Hawthorne, New York, United States

Northwell Health/ RJ Zuckerberg Cancer Center

Lake Success, New York, United States

North Shore University Hospital

Manhasset, New York, United States

Long Island Jewish Medical Center

New Hyde Park, New York, United States

Westchester Medical Center

Valhalla, New York, United States

Brody school of Medicine at East Carolina University

Greenville, North Carolina, United States

ECU Health Medical Center

Greenville, North Carolina, United States

Sanford Fargo Medical Center

Fargo, North Dakota, United States

Oncology Hematology Care Clinical Trials, LLC