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COMPLETED
NCT06153615
NA

Local Sleep in Idiopathic Hypersomnia

Sponsor: Assistance Publique - Hôpitaux de Paris

View on ClinicalTrials.gov

Summary

Idiopathic hypersomnia (IH) is a rare and poorly studied disease characterized by excessive daytime sleepiness different from that of narcolepsy (sleep drunkness non-recuperative naps and nocturnal blackout). Local sleep is a recent concept, proposing a local regulation of the sleep-wake state, characterized by slow waves (SW) restricted to certain regions of a globally awake brain. The investigators are going to investigate whether local sleep could explain the sleepiness of these patients better than the global occurrence of sleep which are not very frequent during daytime tests in IH. The investigators propose to look for local sleep through the detection of local slow waves in the EEG of resting wakefulness and during an attentional task in people with IH compared to people with NT1 (sleepy, but with a different type of sleepiness from IH, more abrupt and including REM sleep) and non sleepy people.

Official title: Sleeping With Open Eyes: Local Sleep in Idiopathic Hypersomnia

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

63

Start Date

2024-02-02

Completion Date

2026-04-29

Last Updated

2026-09-11

Healthy Volunteers

Yes

Interventions

OTHER

EEG (64 electrodes)

EEG recording while awake, at rest then during an attentional cognitive test

OTHER

Cognitive task (SART)

Sustained attention go-no-go task (press a button each time a number is presented on a screen (1/second) except when the 3 appears) Assessment of mental status approximately every 45 seconds (task focus, mind wandering, mental blank, and sleepiness status)

OTHER

Pupillometry and eye tracking

Study of pupil size and gaze path during the cognitive test (correlated with alertness)

OTHER

Thoracoabdominal belts

Abdominal and thoracic belts (used in all nocturnal polysomnographic recordings) for respiratory movement studies (correlated with sleepiness)

Locations (1)

Pitié Salpêtrière

Paris, France