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INtensity of OVarian Stimualtion and Euploid Embryos
Sponsor: Fundación Santiago Dexeus Font
Summary
This randomized trial was designed as a no-inferiority trial aiming to evaluate if the intensity of stimulation (a milder vs a more intense approach) may have an impact on the number of euploid embryos and the morpho kinetic parameters in advanced age women undergoing PGT-A with a PPOS protocol.
Official title: The Impact of Ovarian Stimulation Intensity on Embryo Euploidy in Advanced Age Women
Key Details
Gender
FEMALE
Age Range
38 Years - 42 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2023-12-12
Completion Date
2026-05-15
Last Updated
2025-02-27
Healthy Volunteers
No
Conditions
Interventions
Follitropin-delta (Rekovelle) 20 mcg/day from D1
On day 2 or 3 of the menstrual cycle, daily injections of 20 mcg of Rekovelle (Stimulation Day 1) will be administered. Scan controls blood exams are performed on stimulation days 6, 8, 10 and, according to clinical needs, until trigger day. The dose will be the same during the whole course of stimulation and no dose adjustments will be performed.
Follitropin-delta (Rekovelle) 15 mcg/day from D1
On day 2 or 3 of the menstrual cycle, daily injections of 15 mcg of Rekovelle (Stimulation Day 1) will be administered. Scan controls and blood exams are performed on stimulation days 6, 8, 10 and, according to clinical needs, until trigger day. The dose will be the same during the whole course of stimulation and no dose adjustments will be performed.
Locations (1)
Hospital Universitario Quiron Dexeus
Barcelona, Spain