Clinical Research Directory

Inclusion Criteria: 1. Scheduled to undergo isolated CABG surgery at a hospital within the UPenn Health System 2. Age ≥18 years 3. Ejection fraction ≥50% 4. Transthoracic echocardiography within one year of scheduled surgery date 5. Left heart catheterization within one year of scheduled surgery date 6. English language fluency or facilitated via language interpreter 7. Able to provide informed consent either in English or via a language interpreter 8. Willing to comply with all study procedures Exclusion Criteria: 1. Documented valve (aortic, mitral, tricuspid, or pulmonic) disease (stenosis or regurgitation) moderate or greater. 2. Any CABG surgery with either "possible" or "definite" aortic intervention listed as a planned part of the procedure. plan for either definite or possible surgical intervention. 3. Any CABG surgery with either "possible" or "definite" valve repair/replacement listed as a planned part of the procedure. 4. Having undergone any previous cardiac surgeries (i.e. scheduled with a "REDO" modifier). 5. Proximal/critical left main coronary disease (e.g. greater than or equal to 90% stenosis). 6. Preexisting anomalous coronary arteries 7. Preexisting end-stage renal disease on hemodialysis 8. Preexisting chronic kidney disease (CKD) stage 3, 4, or 5 9. Stroke with residual focal neurological deficit(s) within 90 days of surgery 10. Any of the following presurgical, mechanical circulatory support devices: 1. Intraaortic balloon pump 2. Percutaneous right ventricular assist device (RVAD) 3. Impella 4. Extracorporeal membrane oxygenation (ECMO) 11. Absolute contraindication to echocardiography defined as one or more of the following documented conditions: 1. Esophagectomy 2. Esophagogastrectomy 3. Esophageal trauma 12. Any of these three relative contraindication to TEE: 1. Esophageal varies 2. Gastric bypass surgery 3. Descending thoracic aortic aneurysm 13. Severe pulmonary hypertension defined as: 1. Pulmonary arterial pressure ≥60 mmHg 2. Pulmonary vascular resistance (PVR) ≥3 Woods Units 14. Hemodynamic instability after induction and following placement of an endotracheal tube will be defined as one or more of the following events or scenarios: 1. Placement of an intraaortic balloon pump (IABP) 2. Initiation of venoarterial extracorporeal membrane oxygenation (VAECMO) 3. Placement of a right or left percutaneous mechanical circulatory support device 4. Initiation of epinephrine infusion at a dose ≥ 6 mcg/min for a duration ≥5 minutes 5. Initiation of norepinephrine at a dose ≥8 mcg/min for a duration ≥ minutes 6. Initiation of phenylephrine infusion at a dose ≥100 mcg/min for a duration ≥ minutes 7. Initiation of vasopressin infusion at a dose ≥0.04 units/min for a duration ≥ minutes