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A Real-world, Multi-center, Prospective, Observational Study for PNH in China
Sponsor: AstraZeneca
Summary
As a rare disease listed in the First Catalogue of Rare Diseases in China (National Health Commission of the People's Republic of China, 2019), PNH is poorly studied in China subse-quently leading to the inadequate elucidation of disease characteristics and clinical outcomes. Eculizumab was recently approved by NMPA. The availability of Eculizumab in China pro-vides people living with PNH with a new treatment option that can reduce disease symptoms and prevent the dysregulated complement system from causing further damage. A Phase Ⅳ study is necessary to understand the natural history of disease and the clinical outcomes with different medical interventions.
Official title: A Real-world, Multi-center, Prospective, Observational Study for Paroxysmal Nocturnal Haemoglobinuria (PNH) in China
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
724
Start Date
2023-11-10
Completion Date
2025-12-03
Last Updated
2026-09-24
Healthy Volunteers
No
Conditions
Locations (40)
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Hefei, Anhui, China
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Beijing, Beijing Municipality, China
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Beijing, Beijing Municipality, China
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Guangzhou, Guangdong, China
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Guangzhou, Guangdong, China
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Guangzhou, Guangdong, China
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Nanning, Guangxi, China
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Guiyang, Guizhou, China
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Shijiazhuang, Hebei, China
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Harbin, Heilongjiang, China
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Zhengzhou, Henan, China
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Zhengzhou, Henan, China
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Zhengzhou, Henan, China
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Wuhan, Hubei, China
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Wuhan, Hubei, China
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Changsha, Hunan, China
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Changsha, Hunan, China
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Nanjing, Jiangsu, China
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Nantong, Jiangsu, China
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Xuzhou, Jiangsu, China
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Nanchang, Jiangxi, China
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Nanchang, Jiangxi, China
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Changchun, Jilin, China
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Shenyang, Liaoning, China
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Jinan, Shandong, China
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Qingdao, Shandong, China
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Zibo, Shandong, China
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Linyi, Shangdong, China
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Shanghai, Shanghai Municipality, China
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Shanghai, Shanghai Municipality, China
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Taiyuan, Shanxi, China
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Xi’an, Shanxi, China
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Xi’an, Shanxi, China
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Chengdu, Sichuan, China
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Chengdu, Sichuan, China
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Tianjin, Tianjin Municipality, China
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Tianjin, Tianjin Municipality, China
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Tianjin, Tianjin Municipality, China
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Kunming, Yunnan, China
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Hangzhou, China