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D-SOLVE Cohorts (Cohort a and B)
Sponsor: Hannover Medical School
Summary
Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
750
Start Date
2023-02-22
Completion Date
2026-09-30
Last Updated
2025-03-12
Healthy Volunteers
No
Conditions
Locations (4)
Hannover Medical School, Department of Gastroenterology, Hepatology, Infectious Disease and Endocrinology
Hanover, Germany
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (University of Milan)
Milan, Italy
Institutul de Boli Infectioase "Prof. Dr. Matei Bals"
Bucharest, Romania
Karolinska University Hospital and Karolinska Institutet
Stockholm, Sweden