Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years. * Radiological diagnosis of branch duct IPMN. * Cyst size of 3cm or worrying growth on serial imaging. * Suitable to undergo endoscopy under deep sedation or general anaesthesia. * Willing and able to comply with all trial requirements, including treatment, timing and/or nature of required assessments. * Signed, written informed consent. Exclusion Criteria: * Presence of known or suspected pancreatic cancer or pathologic lymphadenopathy. * Radiological diagnosis of IPMN with any of the following: 1. Main pancreatic duct dilation of \>10 mm 2. Cytology with high grade dysplasia or "suspicious for malignancy" 3. Common bile duct obstruction causing jaundice 4. Septated cysts with \> 4 compartments 5. Epithelial type mural nodules (\> 2mm) 6. Lesions with thick wall/septation (\> 2mm) 7. High-grade communication with the main pancreatic duct 8. Previous aspiration failure due to excessive cyst fluid viscosity * Clinically significant laboratory abnormalities 1. INR \>= 1.7 2. APTT \> 80 secs 3. Platelet count \< 100 x 10E9/L 4. ALT \> 500 U/L 5. Total bilirubin \> 25 umol/L * Evidence of pancreatitis within the last 6 months. * History of hypersensitivity to gemcitabine or paclitaxel. * Concurrent illness that may jeopardise the ability of the patient to safely undergo the procedures outlined in this protocol. * Any medical condition that would, at the discretion of the investigator, interfere with the completion of and/or participation in the protocol. * Presence of any psychological, familial, sociological, or geographical condition potentially hampering compliance with the trial protocol and follow-up schedule, including alcohol dependence or drug abuse. * Pregnancy, lactation, or inadequate contraception.