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NOT YET RECRUITING
NCT06162988
NA

PET Imaging of 68Ga-NOTA-H006 in Malignancy

Sponsor: YiHui Guan

View on ClinicalTrials.gov

Summary

5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages. Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.

Official title: A Study to Evaluate 5T4 Expression in Malignant Tumors Using 68Ga-NOTA-H006

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

15

Start Date

2023-12

Completion Date

2028-12

Last Updated

2023-12-08

Healthy Volunteers

No

Conditions

Interventions

DRUG

68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg.

68Ga-NOTA-H006:PET imaging; 18F-FDG:PET imaging

Locations (1)

Huashan Hospital

Shanghai, China