Clinical Research Directory

Inclusion Criteria: * Patients with clinically significant non-functioning pituitary adenoma treated with surgery during the last ten years * Stable hormone replacement therapy ≥ 6 months * Ability to communicate in Swedish. Exclusion Criteria: * Patients with any other pituitary tumors than non-functioning pituitary adenoma * Patients who possibly need tumor intervention, either with surgery or radiotherapy, within one year * Other diseases or co-morbidities that may have significant impact on the outcome variables, including: * Ongoing substance abuse and/or untreated psychiatric disorder, including psychoses and bipolar disease (except treatment with SSRI (Selective Serotonin Reuptake Inhibitor) and or SNRI (Serotonin-Norepinephrine Reuptake Inhibitor) for mild/moderate depression and/or anxiety which is allowed). * Medical therapy with opioids, sedatives or hypnotics (besides treatment with zopiclone and zolpidem which are allowed). * Current or previous history of neurological diseases with impaired mobility. * High alcohol consumption (more than 14 alcohol units per week) * Ongoing treatment for cancer. * Uncontrolled hypertension or presence of clinically significant cardiac disease * Severe respiratory insufficiency. * Severely impaired hepatic function (ALT (Alanine Aminotransferase) and/or AST (Aspartate Aminotransferase) concentrations two times above the upper limit of normal). * Severely impaired renal function (Glomerular filtration rate \<45 ml/min). * Untreated hypo- or hyperthyroidism * Pregnancy or breast feeding.