Clinical Research Directory

Inclusion Criteria: * \- Subject with grip strength (assessed with a dynamometer) ≥16kg for women and ≥26 kg for men. * 21 ≤ BMI ≤35 * Participant living in a rural or peri-urban area or city dweller, according to the population density grid of the Territorial Observatory (categories 3, 2 or 1 respectively). * Cognitively able to perform tests and answer questionnaires according to the judgment of the recruiting doctor and on the basis of the Mini-Mental State Examination (MMSE) * Available to carry out the entire protocol * Biological assessment considered by the investigator as compatible with participation in the study, * Subject agreeing to give written consent, and registration in the national file of volunteers who lend themselves to research * Person subject to a social security system. Exclusion Criteria: * \- Diabetes treated * Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days preceding inclusion. * Hepatocellular insufficiency, * Heart failure with decompensation, * Renal insufficiency (clearance \<30 ml/min) * Chronic anti-inflammatory treatment, long-term corticosteroid therapy \> 1 month, infiltrations * Antibiotic treatment within 30 days prior to recruitment * Progressive pathology at the time of inclusion (cancer, etc.) * Gastrointestinal pathology deemed incompatible with the protocol * Eating habits incompatible with the protocol (allergies, test food intolerances/aversions, vegan diets, ketogenic diets, etc.) * Unstabilized thyroid diseases * Intense physical activity (activity causing shortness of breath and sweating) \> 10 hours per week * Person who is in a period of exclusion on the National File of Healthy Volunteers * Subject presenting a psychiatric pathology or cognitive disorders making them incapable of giving informed consent. * Subject under guardianship, curatorship, deprived of freedoms or under the protection of justice